Fundación Castilla del Pino

Premios 3ª edición

La 3ª edición (1999) fue concedida al Profesor Donald F. Klein (Columbia University) en reconocimiento a sus investigaciones en el campo de la psicofarmacología.

Donald F. Klein
Curriculum

El Dr. Donald F. Klein nació en la ciudad de Nueva York el 4 de septiembre de 1928. Cursó el bachillerato en el Bronx High School of Science, y en 1947 se graduó en Filosofía y Letras (B.A.) por Colby College de Waterville (Maine) con la calificación de Magna Cum Laude. Posteriormente realizó el Curso de Postgrado en Biología en la Universidad de Nueva York (New York City). En 1952 se licenció por la Facultad de Medicina en la State University de Nueva York.

Entre 1952 y 1953, el Dr. Klein hizo un internado rotatorio en el Marine Hospital, dependiente del Servicio Público de Salud estadounidense (USPHS), en Staten Island, y a continuación realizó la residencia en Psiquiatría en el Creedmoor State Hospital. Hacia la mitad de su residencia, concretamente entre 1954 y 1956, realizó también el servicio militar como cirujano ayudante en el Hospital para Toxicomanía (USPHS) en Lexington, (Kentucky). Se hizo cargo del Servicio de Admisión y de la Unidad de Mujeres.

Una vez concluida su residencia en Psiquiatría, el Dr. Klein fue designado Asociado de Investigación en el Creedmoor Institute for Biological Studies. En 1959 su nuevo destino es Hillside Hospital, donde llega a ocupar el puesto de Director Médico de Investigación y Evaluación, siendo nombrado además Psiquiatra Jefe del Queens Hospital Center, institución asociada.

En 1976, el Dr. Klein se incorporó como docente al Departamento de Psiquiatría del Colegio de Médicos y Cirujanos de la Universidad de Columbia. En la actualidad ostenta los cargos de Catedrático de Psiquiatría así como Psiquiatra Residente del Presbyterian Hospital de la Universidad de Columbia. Además, es Director de Investigación Psiquiátrica y del Departamento de Terapéutica del New York State Psychiatric Institute

Asimismo, el Dr. Klein ha sido Catedrático visitante de Psiquiatría en la Universidad de Hawaii, en el Albert Einstein College of Medicine, y en la Universidad de Auckland, Nueva Zelanda. Fue Presidente del Colegio Americano de Neuropsicofarmacología (American College of Neuropsychopharmacology), de la Sociedad para la Investigación Psiquiátrica (Psychiatric Research Society), y de la Asociación Americana de Psicopatología (American Psychopathological Association). Es miembro vitalicio de la Asociación Psiquiátrica Americana (American Psychiatric Association), además del Colegio Americano de Neuropsicofarmacología (American College of Neuropsychopharmacology). En la actualidad preside la Sociedad Americana de Psicofarmacología Clínica (American Society of Clinical Psychopharmacology) y de la Fundación Nacional para Trastornos Depresivos (National Foundation for Depressive Illness).

El Dr. Klein ha ejercido como asesor federal para numerosas y prestigiosas agencias: la Comisión Consultiva de Neurofarmacología del Organismo para el Control de Alimentos y Medicamentos (Food and Drug Administration, FDA); el Centro de Investigación de Toxicomanía (Center for Studies of Narcotic and Drug Abuse); el Instituto Nacional de Salud Mental (NIMH), sección de Estudios de Psicofarmacología Clínica; la Comisión Consultiva de Psicoterapia para el Gabinete de Evaluación de Tecnología (Office of Technology Assessment); el Instituto Nacional de Gerontología (National Institute of Aging), y la Comisión Especial para el Estudio Científico del Alcoholismo Clínico: Agencia de Veteranos de Guerra (Veterans Administration). Fue asesor de la Agencia de Alcoholismo, Toxicomanía y Salud Mental (Alcoholism, Drug Abuse and Mental Health Administration) entre 1988 y 1989, desempeñando el cargo de Asesor Científico Jefe de dicho organismo entre 1989-1990. Durante ese período trabajó intensamente para crear los Departamentos para el Desarrollo de Fármacos (Medication Development Divisions) en el Instituto Nacional de Toxicomanía (National Institute for Drug Abuse, NIDA), y en el Instituto Nacional de Salud Mental (NIMH). Actualmente preside la Comisión NIDA que estudia el Desarrollo de Fármacos dentro la Agencia de Veteranos de Guerra.

El doctor es integrante del equipo de redacción de diferentes revistas profesionales, como son: Journal of Clinical Psychopharmacology, Comprehensive Psychiatry, The Journal of Abnormal Child Psychology así como Archives of General Psychiatry.

Al Dr. Klein le han sido adjudicadas diversas ayudas federales a la investigación, y actualmente dirige uno de los once centros de investigación clínica sobre salud mental del NIMH.

Entre los muchos galardones que ha recibido se destacan: Premio A.E. Bennet a la Investigación Neuropsiquiátrica (1964); Premio de Investigación de la Asociación Nacional de Hospitales Psiquiátricos Privados (National Association of Private Psychiatric Hospitals) (1971); Premio Samuel W. Hamilton de la Asociación Americana de Psicopatología (1980); Premio de Psiquiatría del Taylor Manor Hospital (1985); Premio del Foundation Fund a la Investigación Psiquiátrica (1988); Premio William R. McAlpin al Avance en Investigación (1988); Medalla de Oro de la Sociedad de Psiquiatría Biológica (Society of Biological Psychiatry) (1990); Premio de Investigación Heinz E. Lehman (1991); Premio Paul Hoch por Servicios Distinguidos del Colegio Americano de Neuropsicofarmacología (1991), y Premio de Psiquiatría William A. Console (1992).

El Dr. Klein fue co-autor del primer libro de texto sobre la psicofarmacología clínica, Diagnosis and Drug Treatment of Psychiatric Disorders (Diagnóstico y tratamiento farmacológico de los trastornos psiquiátricos), publicado en 1969. Esta obra constituye una aportación fundamental en el avance hacia un diagnóstico sistemático y objetivo en psiquiatría. El Dr. Klein también ha colaborado en la Comisión Consultiva para Nomenclatura y Estadística del DSM-III, que culminó en la publicación del texto DSM-III.
El Dr. Klein es autor de catorce libros, 352 artículos originales en revistas profesionales acreditadas, 108 capítulos de libros y unas 100 publicaciones más.

El trabajo científico del Dr. Klein se ha centrado en la evaluación de terapias psiquiátricas, tanto psicoterapéuticas como farmacoterapéuticas. Ha contribuido a la nosología psiquiátrica y ha ofrecido orientaciones diferenciales para regímenes de tratamiento en los campos del trastorno de pánico, la agorafobia, las fobias específicas y sociales, las depresiones endogenomórfica y atípica, la esquizofrenia asocial de la infancia y el trastorno de atención. Últimamente ha colaborado en estudios sobre la biología y la genética del trastorno de ansiedad.

Curriculum

DONALD F. KLEIN, M.D. as of January, 2003
New York State Psychiatric Institute
College of Physicians & Surgeons
Columbia University

EDUCATION:
BA, Colby College, Waterville, Maine, 1947
New York University Graduate School Program in Biology, 1947-1948
MD, State University of NY, College of Medicine, New York City, 1952
Doctor of Science (Hon.) State University of New York, Downstate Medical Center, 1998

INTERNSHIP & RESIDENCY:
Rotating Internship, USPHS Hospital, Staten Island, NY, 1952-1953
Residency in Psychiatry, Creedmoor State Hospital, 1953-1954, and 1956-1958

MILITARY SERVICE:
Senior Assistant Surgeon (R) USPHS Staff Psychiatrist USPHS Hospital, Lexington, Kentucky, 1954-1956

HONORS & AWARDS:
Magna Cum Laude, 1947
Phi Beta Kappa, 1947
AE Bennett Neuropsychiatric Research Award, Third Place, 1964
National Association of Private Psychiatric Hospitals Research Award, 1965, 1971
Samuel W. Hamilton Award, APPA, 1980
Taylor Manor Hospital Psychiatric Award, 1985
Foundation's Fund Prize for Research in Psychiatry, 1988
William R. McAlpin Award for Research Achievement, N.A.M.H., 1988
The Society of Biological Psychiatry Gold Medal Award, 1990
Heinz E. Lehman Research Award, New York State, 1991
Paul Hoch Distinguished Service Award, ACNP, 1991
William A. Console, M.D. Award in Psychiatry, SUNY Alumni Society, 1992
Thomas W. Salmon Medal for Distinguished Service in Psychiatry, New York Academy of Medicine, 1993.
Department of Veteran Affairs Certificate of Appreciation "Chairman VA/NIDA Review Board", 1995
Society of Biological Psychiatry, Lifetime Achievement Award, 1996.
Exemplary Psychiatrist Award for 1997, National Alliance for the Mentally Ill
Columbia University, College of Physicians and Surgeons, Deans Distinguished Lectureship in the Clinical Sciences, 1998
Castillo del Pino Prize for Achievement in Psychiatry, 1999
Office of Clinical Trials, Columbia University/New York Presbyterian Hospital,
Certificate for completion of course on Good Clinical Practices, 2000
Medical Society of the State of New York
Citation commemorating 50 years of dedication to medicine, 2002
Castle Connolly Medcal LTD
America's Top Dotors & Top Doctors: New York Metro Area

BOARD STATUS:
Qualified Psychiatrist, State of New York, 1959
Diplomate, American Board of Psychiatry and Neurology in Psychiatry, 1959
Diplomate, American Board of Clinical Pharmacology, 1992, Certificate #92109

TYPE OF PRACTICE:
Psychiatry and Psychopharmacology

LICENSURE STATUS:
Diplomate, National Board Medical Examiners, 1953
License # 73940, New York, 1953

PRESENT POSITIONS:
Professor of Psychiatry, Columbia University, 1978-
Attending Psychiatrist, New York Presbyterian Hospital, 1977-
Director of Psychiatric Research, New York State Psychiatric Institute, 1976 -
Director of Department of Therapeutics, New York Psychiatric Institute, 1976-
Visiting Professor of Psychiatry, Albert Einstein College of Medicine, 1997-
Consultant, NIDA, 1990-
Special Advisory Board, Freedom From Fear, Staten Island, NY, 1992-
CPMC Clinical Research & Development Fund Committee, 1992-
Psychiatrist, Montefiore Medical Center, 1995-
Adjunct Professor of Psychology, Queens College, City University of New York, 1969-
Chairman of the Scientific Advisory Board, Vela Pharmaceuticals, 1999-
Consultant, Institute for Healthcare Quality, 1996-
ACNP Liaison Committee with Governmental Agencies and the Pharmaceutical Industry, 1999-
Visiting Professor of Psychiatry and Behavioral Sciences, 2001-
Assistant Treasurer of ASCP, 2001-
VivoMetrics Scientific Advisory Board Member, 2002-
Alexza Scientific Adviory Board Member, 2002-
The Scandinavian College of Neuro-Psychopharmacology, 2003-
Foreign Corresponding Member of SCNP, 2003-
ISI Highly Cited Member (Publication #A01827-2002X), 2003-

RELEVANT PAST POSITIONS:
Consultant, Psychotherapeutic Medication Development Program, NIMH, 1992-96
Chairman, NIDA/VA Medication Development Review Group, 1991-96
Senior Science Advisor, ADAMHA, 1989-1990
Consultant, ADAMHA, 1988-1989
Chairman, Texas Department of Mental Health and Mental Retardation
Research Advisory Council, 1983-1985
Consultant, Long Island Jewish-Hillside Medical Center, 1976-1985
Full Attending Psychiatrist, Queens Hospital Center, 1972-1985
RELEVANT PAST POSITIONS (Con't):
Lecturer, Columbia University, 1976-1978
Visiting Professor Psychiatry, Albert Einstein College of Medicine, 1976-1977
Visiting Professor, University of Hawaii, 1977, 1985, 1986, 1993
Professor of Psychiatry, State University of NY, College of Medicine, Stony Brook,
1972-1976
Visiting Professor Psychiatry, University of Auckland, New Zealand, 1975
Psychiatrist-in-Chief, Queens Hospital Center, 1970-1971
Director, Research & Evaluation, Department of Psychiatry, Long Island Jewish-Hillside Medical Center, 1972-1976
Chairman, Committee on Research & Publication, Long Island Jewish-Hillside Medical Center, 1972-1975
Medical Director for Evaluation, Hillside Hospital, 1970-1971 Director of Research,
Hillside Hospital, 1965-1970
Senior Staff Psychiatrist (Research), Hillside Hospital, 1965 NIMH Mental Health
Career Investigator, Hillside Hospital, 1961-1964
Research Associate, Hillside Hospital, 1959-1964
Research Associate, Creedmoor Institute for Psychobiologic Studies, 1957-1959
Candidate NY Psychoanalytic Institute, 1957-1961

SOCIETIES:
American Society of Clinical Psychopharmacology, Vice President, 1997- , President, 1992-1996
National Foundation for Depressive Illness, President, 1983-
National Depressive and Manic Depressive Association, Scientific Advisory Board, 1986-1999; Member 1986-
American Association for the Advancement of Science, 1983, Fellow, 1997-
American College of Neuropsychopharmacology - Life Fellow
Chairman Credentials Committee, 1976-1978
Program Committee, 1978
President-Elect, 1980, President, 1981
Chairman, Committee on Public Concern, 1983, 1987 and 1988; Consultant 1989-
Ad Hoc Awards Committee, 1984
Task Force for Creation of Statement of Principles (DF Klein & N Schooler), 1994
(accepted by ACNP Council, December 1995)
Nominating Committee, 1989; Chairman 1990-1991; Ex-Officio, 1992
Planning Group, Committee on Relations with Advocacy Groups
Chairman, Task Force for the Development of a Non-Profit
Foundation to Investigate Issues of Scientific Misconduct, 1989-1992
History Task Force, 1994-1996
Co-Chairman, Task Force on Ethical Issues in Controlled Clinical Trials, 1994-1996 Co-Chairman Liaison Committee With Government Agencies & the Pharmaceutical Industry, 1994-1996; Member 1999-2001
American Psychiatric Association - Life Fellow
DSM-III Task Force on Nomenclature & Statistics
DSM-III Anxiety and Dissociative Disorders Advisory Committee
SOCIETIES (Cont'd):
DSM-III Personality Disorders Advisory Committee
DSM-III Impulse Control Disorders Advisory Committee
DSM-III-R Mood Disorders Advisory Committee
DSM-III-R Anxiety Disorders Advisory Committee
DSM-III-R Personality Disorders Advisory Committee
DSM-IV Mood Disorders Advisory Committee
Chairman, Task Force on Guidelines for the Protection of Human Subjects in
Psychiatric Research, 1977-1979; 1982-1984; Member, 1979-1981
Consultant to APA Task Force on Treatment of Psychiatric Disorders, 1986-
Anxiety Disorders Association of America, Scientific Advisory Board, 1996-99
Task Force on Psychopharmacologic Criteria Development, 1977-1979
Chairman, Hofheimer Prize Board, 1973-1975
Task Force on Methadone & Narcotic Antagonist Evaluation,
Task Force on Nomenclature & Statistics, 1974-1979
American Psychopathological Association - Member
Treasurer, 1972-1975
Program Chairman, 1975, 1977-1079
Secretary, 1976
Vice-President, 1977
President-Elect, 1978-1979
President, 1979-1980
Councillor, 1980-1981
Collegium Internationale Neuro-Psychopharmacologicam (CINP), Fellow (1972)
International Neuropsychology Society, Executive Committee, 1967
Psychiatric Research Society, President, 1980
Information Exchange on Young Adult Chronic Patients, National Advisory Board,
1983-
Professional Board of Advisors, The Foundation of Thanatology Psychiatric Research Society
Chairman, Steering Committee, 1977
Steering Committee, 1974-1976
Royal College of Psychiatrists - Founding Member, Fellow until 1996
Fellow Society of Life History Research in Psychopathology
Society of Biological Psychiatry, Senior Member
Society of Neuroscience
Society for Psychophysiological Research
Society for the Study of Social Biology
Association for Clinical Psychosocial Research - Fellow
American Society for Clinical Pharmacology and Therapeutics
European Brain and Behaviour Society
International Brain Research Organization
Society for Light Treatment and Biological Rhythms
Lyme Research Foundation, Inc., Scientific Advisory Council, 1993-
European Certificate in Anxiety and Mood Disorders, Board of Advisors, 1994- American Statistical Association, 1994-
SOCIETIES (Cont'd):
National Anxiety Disorders Screening Day, Scientific Advisory Board, 1994-
National Anxiety Foundation, Scientific Advisory Board, 1995-
Mental Illness Foundation, Medical Advisory Board, 1996-
American Association of Applied and Preventive Psychology, 1996-
International Academy for Biomedical and Drug Research, corresponding member,
1996-
International Society for the Advancement of Respiratory Psychophysiology, member,
1997-
American Psychological Society, 1997-
New York County Medical Society, 1953-
Global Alliance of Mental Illness Advocacy Networks (GAMIAN) Advisory Board,
1998-
III Congres de la Federation Internationale Francophone de Psychiatrie, Member, 2000 -
International Society for Research in Child & Adolescent Psychpathology, 2000-

FEDERAL CONSULTANTSHIPS:
NIAAA Board of Scientific Counselors, 1996-1999
Consultant, Medical Research Council of New Zealand, 1986-
Affective and Anxiety Disorder Research Branch, NIMH, Workshop on
Recommendations for Future Research, 1986
Advisory Group, NIMH Depression Awareness, Recognition, and Treatment (D/ART)
Program, 1985
NIMH Workshop on Developing Guidelines for the Clinical Evaluation of
Antidepressant Drugs, 1985
Veterans Administration, Ad Hoc Scientific Review Committee for Clinical Research in
Alcoholism, 1984
National Institute of Health, Consultant to Clinical Center, 1983
Advisory Panel on Psychotherapy, Office of Technology Assessment, Wash. DC,
Background Paper #3: The Efficacy & Cost Effectiveness of Psychotherapy, 1980
Federal Hospital Council - Member, 1976-1980
Advisory Group, CRB-NIMH Psychotherapy of Depression Collaborative Research
Progam, 1979
National Institute of Education, Consultant, 1976
Clinical Psychopharmacology Study Section, NIMH, 1971-1975, Chairman, 1973-1975

EDITORIAL BOARDS:
Center for Studies of Narcotic & Drug Abuse, 1973
Neuropharmacology Advisory Committee, Food & Drug Administration, 1971
Depression & Anxiety, 1993
Archives of General Psychiatry, 1975-
Comprehensive Psychiatry, 1977-
European Psychiatry 1992-
Evolutionary Psychology 2001-
Handbook of Anxiety (Roth, Noyes & Burrows, Eds.), 1985-
EDITORIAL BOARDS (Con't):
International Journal of Methods in Psychiatric Research, 1991- Journal of Clinical
Psychiatry, 1987-
Journal of Clinical Psychopharmacology, 1979-
Journal of Psychiatric Research, 1983- Journal of Abnormal Child Psychology, 1976-98
NYS District Branch Newsletter, 1975-1985
Health and Medical Horizons, Board of Advisers, 1982-97
Evolutionary Psychology 2001-

GRANTS:
MH-4798 - NIMH Career Investigator - "Psychiatric Reaction Patterns to Psychotropic Drugs 7/1/61 - 6/30/64

MH-08004 - NIMH "Development of Drug-Sensitive Behavioral Measures" 1/1/64 -
12/31/66

Dreyfus Charitable Fund- "Psychotropic Effects of Dilantin" 1/1/66 - 12/31/66

MH-12237 - NIMH "Drug Pilot Study in Young Psychiatric Patients" 1/1/66 - 12/31/68

MH-145l4 - NIMH "Imipramine Treatment of School Phobia" 1/1/68 - 8/3/71

MH-18579 - NIMH "Comparative Drug Effects in Hyperkinetic Chi1dren" 9/1/70 - 8/31/73

MH-21337 - NIMH "Drugs in the Aftercare Treatment of Schizophrenia" 1/1/72 - 9/1/75

MH-23007 - NIMH "Imipramine Behavior Therapy & Phobia" 9/1/72 - 2/28/78

MH-18579 - NIMH "Methylphenidate and Behavior Modification
in MBD Children" 9/1/73 - 8/31/78

MH-15144 - "Research Training in Depression and Schizophrenia", Associate Program
Director, 7/1/77-6/30/82

MH-30906 - NIMH "MHCRC-New York State Psychiatric Institute" 8/1/78 - 7/31/89,
8/1/89 - 7/31/94 & 8/1/94 - 7/31/99

MH-33422 - NIMH "Pharmacology & Physiology of Panic Disorder" 7/1/79 - 6/30/88

DACB1RO1DAO3836-01A1786-689, NIDA, "Treatment of Cocaine Abuse With
Imipramine" 7/86 - 6/89

MH-37592 - NIMH "Psychobiology, Genetics & Treatment of Anxiety Disorders" 9/1/83 - 4/30/00

Pfizer, Inc., "Sleep Apneic Threshold in Panic Disorder and Normals" 3/1/00 - 2/29/01

2000 NARSAD Distinguished Investigator Award, "Investigation of Endogenous CO2 Sensitivity Using the Sleep Apneic Threshold in Panic and Depression Comorbid with Panic" 5/15/00 - 5/15/01

Diagnosis & Drug Treatment of Psychiatric Disorders, Klein, DF, & Davis, JM, Baltimore, Maryland, Williams & Wilkins, 1969.

Psychiatric Case Studies: Treatment, Drugs and Outcome, Baltimore, Maryland, Williams & Wilkins, 1972.

Pharmacotherapy & Psychotherapy: Paradoxes, Problems & Progress, Group for the Advancement of Psychiatry, Vol. 9, Report #93, 1975. (Formulated by the Committee on Research: Members, Morris A. Lipton, Stanley H. Eldred, Louis A. Gottschalk, Donald F. Klein, Gerald L. Klerman, Ralph R. Notman, & Eberhard H. Uhlenhuth).

Progress in Psychiatric Drug Treatment, Klein, DF, & Gittelman-Klein, R (Eds.), New York, Brunner/Mazel, Vol. I, 1975 and Vol II, 1976.

Evaluation of Psychological Therapies: Psychotherapies, Behavior Therapies, Drug Therapies & Their Interactions, Spitzer, RL, & Klein DF (Eds.), Baltimore, Maryland, Johns Hopkins University Press, 1976.

Estudios de Casos Psiquiatricos: Tratamiento, Drogas y Resultado, Spanish Edition of Klein (1972), Editorial Troquel S.A., Buenos Aires, 1977

The Physicians Handbook on Depression. Project directed by Donald F. Klein, in consultation with Joseph Mendels & James G. Price, Pfizer, Inc., 1977.

Critical Issues in Psychiatric Diagnosis. Spitzer, RL, & Klein, DF (Eds.), Raven Press, New York, 1978.

Diagnosis & Drug Treatment of Psychiatric Disorders: Adults & Children (2nd Edition) Klein, DF, Gittelman, R, Quitkin, F & Rifkin A, Williams & Wilkins, Baltimore, Maryland,
1980.

Anxiety: New Research & Changing Concepts, Klein, DF, & Rabkin, JG (Eds.), Raven Press, New York, NY, 1981.

Mind, Mood & Medicine: A Guide to The New Biopsychiatry. Wender, PH & Klein, DF, Farrar Strauss & Giroux, New York, NY, 1981 and New American Library, New York, NY 1982. Japanese edition, 1990. Brazilian edition, 1990.

Modern Problems of Pharmacopsychiatry (Vol. 22): Anxiety. Klein, DF, Liebowitz, MR, Fyer, AJ & Gorman, JM (Eds.), S. Karger A.G., Basel, Switzerland, 1987.

Do You have a Depressive Illness? Klein, DF & Wender, PH, New American Library, New York, 1988.

Understanding Depression. Klein, DF & Wender, PH, Oxford University Press, New York, 1993.
Psychotherapeutic Drug Manual, Zito, JE (Ed.), John Wiley & Sons, Inc., New York, 1994. (Formulated by the New York State Office of Mental Health Committee on Therapeutics; Chairman: Robert Cancro; Secretary: Julie Magnum Zito; Members: Magda Campbell, Thomas J. Craig, Donald F. Klein, Heinz E. Lehman, John Oldham, Kurt Patton, Zebulon Paintor, Herman van Praag, Jan Volavka.)

The American Psychiatric Press Textbook of Psychopharmacology, Schatzberg, AF and Nemeroff, CB (Eds.), Klein, DF, section editor: Psychopharmacological Treatment. American Psychiatric Press, Washington, DC, 1995.

Current Neurologic Drugs, Rowland, LP & Klein, DF (Eds.), Current Medicine, Philadelphia, PA, 1996.

Current Psychotherapeutic Drugs, Klein, DF & Rowland, LP (Eds.), Current Medicine, Philadelphia, PA, 1996.

The American Psychiatric Press Textbook of Psychopharmacology (Second Edition), Schatzberg, AF and Nemeroff, CB (Eds.), Klein, DF, section editor: Principles of Psychopharmacology. American Psychiatric Press, Washington, DC, 1998.

1. Whittier, JR, Klein, DF, Levine, G & Weiss, D: Mepazine (Pacatal): Clinical trial with
placebo control and psychological study. Psychopharmacologia 1:280-287, 1960.

2. Whittier, JR, Korenyi, C, Klein, DF & Foley, W: Prevention of degenerative disease: A controlled study of anticoagulant prophylaxis. J Chronic Dis 14:202-212, 1961.

3. Blumberg, AG & Klein, DF: Severe papilledema associated with drug therapy. Am J Psychiatry 118:168-170, 1961.

4. Pollack, M, Karp, E, Krauthamer, G, Klein, DF & Fink, M: Neuropsychologic response patterns of some psychotropic drugs. Neuropsychopharmacology 2:381-384, 1961.

5. Kramer JC, Klein DF & Fink M: Withdrawal symptoms following discontinuation of imipramine therapy. Am J Psychiatry 118:549-550, 1961.

6. Klein DF & Fink M: Psychiatric reaction patterns to imipramine. Am J Psychiatry 119:432-438, 1962.

7. Klein DF & Fink M: Behavioral reaction patterns with phenothiazines. Arch Gen Psychiatry 7:449-459, 1962.

8. Kramer, JC, Klein, DF & Fink, M: Imipramine as an adjunct to phenothiazine therapy. Compr Psychiatry 3:377-380, 1962.

9. Klein, DF & Fink, M: Multiple item factors as change measures in psychopharmacology. Psychopharmacologia 4:43-52, 1963.

10. Blumberg, AG, Klein, DF & Pollack, M: Age related changes in blood pressure with chlorpromazine and imipramine. Excerpta Medica International Congress Series #57. Sixth International Congress of Gerontology, 1963.

11. Belmont I, Pollack, M, Willner, A, Klein, DF & Fink, M: The effects of imipramine and chlorpromazine on perceptual analytic ability, perceptual responsivity and memory as revealed in Rorschach response. J Nerv Ment Dis 137:42-50, 1963.

12. Gittelman, R, Klein, DF & Pollack, M: Effects of psychotropic drugs on long-term adjustment: A review. Psychopharmacologia 5:317-338, 1964.

13. Blumberg, AG, Klein, DF & Pollack, M: Effects of chlorpromazine and imipramine on systolic blood pressure in psychiatric patients: Relationships to age, diagnosis and initial blood pressure. J Psychiatry Res 2:51-60, 1964.

14. Belmont, I, Birch, HG, Klein, DF & Pollack, M: Perceptual evidence of CNS dysfunction in schizophrenia. Arch Gen Psychiatry 10:395-408, 1964.

15. Klein, DF: Management problems at Hillside Hospital 1960 and 1963. J Hillside Hosp 13:79-94, 1964.

16. Klein, DF: Delineation of two drug-responsive anxiety syndromes. Psychopharmacologia 5:397-408, 1964. Japanese version appeared in Archives of Psychiatric Diagnostic and Clinical Evaluation 4(16):505-508, 1993.

17. Klein, DF: Behavioral effects of imipramine and phenothiazines: Implications for a psychiatric pathogenetic theory and theory of drug action. Recent Adv Biol Psychiatry 7:273-287, 1964.

18. Pollack M, Klein DF, Willner A, Blumberg AG & Fink, M: Imipramine-induced behavioral disorganization in schizophrenic patients: Physiological and psychological correlates. Recent Adv Biol Psychiatry 7:53-61, 1964.

19. Fink, M, Pollack, M, Klein, DF, Blumberg, AG, Belmont, I, Karp, E, Kramer, JC & Willner A: Comparative studies of chlorpromazine and imipramine. I. Drug discriminating patterns. Neuropsychopharmacology 3:370-372, 1964.

20. Pollack, M, Karp, E, Belmont, I, Willner, A, Klein, DF, & Fink, M: Comparative studies of chlorpromazine and imipramine. II. Psychological performance profiles. Neuropsychopharmacology 3:374-376, 1964.

21. Klein, DF: Visual hallucinations with imipramine. Am J Psychiatry 121:911-914, 1965.

22. Fink, M, Klein, DF & Kramer, JC: Clinical efficacy of chlorpromazine-procyclidine combination, imipramine and placebo in depressive disorders. Psychopharmacologia 7:27-36, 1965.

23. Burnett, LL & Klein, DF: A guide for the psychiatric case study. J Hillside Hosp 14:54-68, 1965.

24. Blumberg, AG & Klein, DF: Methoxy-catecholamine excretion and the mecholyl test. J Psychiatric Res 3:239-254, 1965.

25. Levenstein, S, Pollack, M & Klein, DF: Follow-up study of formerly hospitalized psychiatric patients: Procedural considerations in data collection. J Hillside Hospital 15:(3-4)152-164, 1966.

26. Klein, DF: Chlorpromazine-procyclidine combination, imipramine and placebo in depressive disorders. Can Psychiatric Assoc J 11:Sl46-S149, 1966.

27. Levenstein, S, Klein, DF & Pollack, M: Follow-up study of formerly hospitalized voluntary psychiatric patients: The first two years. Am J Psychiatry 122:1102-1109, 1966.

28. Kennard, MA, Pollack, M & Klein, DF: The EEG qualities in a group of young adult hospitalized psychiatric patients. Recent Adv Biol Psychiatry 8:277-282, 1966.

29. Blumberg, AG & Klein, DF: Age, base blood pressure, diagnosis, and mecholyl test response. Psychosom Med 28:789-794, 1966.

30. Blumberg, AG & Klein, DF: Psychotropic drugs, mecholyl test and outcome. Excerpta Medica International Series 129:1212-1216, 1966.

31. Klein, DF: Diagnostic prediction of psychotropic drug effect: Global outcome. Excerpta Medica International Series 129:736-740, 1966.

32. Pollack, M, Levenstein, S & Klein, DF: A three year post-hospital follow-up of psychiatric patients: First hospitalization in adolescence vs. adulthood. Int J Child Psychiatry 33:224-225, 1966.

33. Klein, DF: Dilantin screening study in hospitalized psychiatric patients. 18th International Congress of Psychology, Symposium. 1966, pgs. 75-82.

34. Klein, DF & Cleary, TA: Platonic true scores and error in psychiatric rating scales. Psychol Bull 68: 77-80, 1967.

35. Klein, DF: Importance of psychiatric diagnosis in prediction of clinical drug effects. Arch Gen Psychiatry 16:118-126, 1967.

36. Klein, DF & Greenberg, IM: Behavioral effects of diphenylhydantoin in severe psychiatric disorders. Am J Psychiatry 124:847-849, 1967.

37. Klein, DF: Treatment of phobias characterized by separation anxiety. International Drug Therapy Newsletter 2:16, 1967.

38. Quitkin, FM & Klein, DF: Follow-up of treatment failure: Psychosis and character disorder. Am J Psychiatry 124:499-505, 1967.

39. Klein, DF: Discussion of psychotropic effect of diphenyl-hydantoin (DPH). Int J Neuropsychiatry 3:Suppl. 2,S63, 1967.

40. Pollack, M, Levenstein, S & Klein, DF: A three year post-hospital follow-up of adolescent and adult schizophrenics. Am J Orthopsychiatry 38:94-109, 1968.

41. Blumberg, AG & Klein, DF: Psychiatric diagnosis, activation and radioactive iodine uptake. Arch Gen Psychiatry 18:601-611, 1968.

42. Rosen, B, Klein, DF, Levenstein, S & Shahinian SP: Social competence and posthospital outcome. Arch Gen Psychiatry 19:165-170, 1968.

43. Klein, DF, Honigfeld, G & Feldman, S: Prediction of drug effect by diagnostic decision tree. Dis Nerv Syst Suppl 29:159-187, 1968.

44. Klein, DF: Psychiatric diagnosis and a typology of clinical drug effects. Psychopharmacologia 13:359-386, 1968.

45. Gittelman-Klein, R & Klein, DF: Marital status as a prognostic indicator in schizophrenia. J Nerv Ment Dis 147:289-296, 1968.

46. Feldman, S, Klein, DF & Honigfeld, G: A comparison of successive screening and discriminant function techniques in medical taxonomy. Biometrics 25:725-734, 1969.

47. Gittelman-Klein, R & Klein, DF: Premorbid asocial adjustment and prognosis in schizophrenia. J Psychiatric Res 7:35-53, 1969.

48. Quitkin, FM & Klein, DF: Two behavioral syndromes in young adults related to possible minimal brain dysfunction. J Psychiatric Res 7:131-142, 1969.

49. Rosen, B, Klein, DF, Levenstein, S & Shahinian SP: Social competence and posthospital outcome among schizophrenic and non-schizophrenic psychiatric patients. J Abnorm Psychol 74:401-404, 1969.

50. Honigfeld, G, Klein, DF & Feldman, S: Prediction of psychopharmacologic effect in man: Development and validation of a computerized diagnostic decision tree. Comput Biomed Res 2:350-361,1969.

51. Pollack, M, Woerner, MG, Goldberg, P & Klein, DF: Siblings of schizophrenic and non-schizophrenic psychiatric patients: Psychopathology and gender concordence. Arch Gen Psychiatry 20:652-658, 1969.

52. Blumberg, AG & Klein, DF: Chlorpromazine-procyclidine and imipramine: Effects on thyroid function in psychiatric patients. Clin Pharmacol Ther 10:350-354, 1969.

53. Mendel, JC & Klein, DF: Anxiety attacks with subsequent agoraphobia. Compr Psychiatry 10:190-195, 1969.

54. Rabiner, CJ & Klein, DF: Imipramine treatment of school phobia. Compr Psychiatry 10:387-390, 1969.

55. Klein, DF & Cleary, TA: Platonic true scores: Further comment. Psychol Bull 71(4):278-280, 1969.

56. Rosen, B, Klein, DF & Gittelman-Klein, R: Sex differences in the relationship between premorbid asociality and posthospital outcome. J Nerv Ment Dis 149(5):415-420, 1969.

57. Klein, DF: The prospective study of bereavement. Arch Foundation of Thanatology 1:13, 1969.

58. Pollack, M, Jaffe, R, Woerner, MG & Klein, DF: Fourteen- and-six-per-second positive spikes in adolescent and young adult psychiatric patients and their siblings. Proceedings of the American Psychological Assoc, 1969.

59. Klein, DF: Drugs and schizophrenia: Critical evaluations. Int J Psychiatry 8:734-739, 1969.

60. Glick, ID, Hauptman, B & Klein, DF: Pseudo-pregnancy treatment of periodic psychiatric illness: A pilot study. Psychiatr Quarterly 44:1-5, 1970.

61. Cohen, M & Klein, DF: Drug abuse in a young psychiatric population. Am J Orthopsychiatry 40(3):448-455, 1970.

62. Cohen, M, Klein, DF & Struve, F: Relationship between electroencephalographic and sociometric variables among psychiatric patients. Am J Psychiatry 127(1):137-141, 1970.

63. Gittelman-Klein, R & Klein, DF: Relationships of the mecholyl test, premorbid asocial functioning and long-term outcome in schizophrenia. J Nerv Ment Dis 150(4):301-306, 1970.

64. Klein, DF, Honigfeld, G, Burnett, LL, Steckler, M, Leader, M & Forman, M: Automating the psychiatric case study. Compr Psychiatry 11(6):518-523, 1970.

65. Klein, DF: Imipramine treatment of school phobia. Psychopharm Bull 6:32-33, 1970.

66. Pollack, M, Woerner, M & Klein, DF: A comparison of twin and sibling studies for a developmental theory of schizophrenia. Acta Geneticae Medical et Gamellologia 19:303-304, 1970.

67. Honigfeld, G & Klein, DF: The Hillside Hospital treatment evaluation program: Clinical and basic research. Suppl to Dis Nerv Syst 31:11, 1970.

68. Woerner, MG, Pollack, M & Klein, DF: Birth weight and length in schizophrenics, personality disorders and their siblings. Br J Psychiatry 118:461-464, 1971.

69. Rosen, B, Klein, DF & Gittelman-Klein, R: The prediction of rehospitalization: The relationship between age of first psychiatric treatment contact, marital status and premorbid asocial adjustment. J Nerv Ment Dis 152(1):17-22, 1971.

70. Rifkin, A, Quitkin, F, Carrillo, C & Klein, DF: Very high dosage fluphenazine for non-chronic treatment-refractory patients. Arch Gen Psychiatry 25:398-403, 1971.

71. Rosen, B, Engelhardt, DM, Freedman, N, Margolis, R & Klein, DF: The hospitalization proneness scale as a predictor of response to phenothiazine treatment: II. Delay of psychiatric hospitalization. J Nerv Ment Dis 152(6):405-411, 1971.

72. Cohen, M & Klein, DF: A measure of severity of multi-drug use. Intl Pharmacopsychiatry 6:83-91, 1971.

73. Blumberg, AG, Cohen, M, Heaton, AM & Klein, DF: Covert drug abuse among voluntary hospitalized psychiatric patients. JAMA 217(12):1659-166l, 1971.

74. Gittelman-Klein, R & Klein, DF: Controlled imipramine treatment of school phobia. Arch Gen Psychiatry 25:204-207, 1971.

75. Saraf, K & Klein, DF: The safety of a single daily dose schedule for imipramine. Am J Psychiatry 128(4):115-116, 1971.

76. Klein, DF: Youthful rebels - diagnosis and treatment. Adolescence 7(27):351-369, 1972.

77. Struve, FA, Becka, DR & Klein, DF: B-Mitten EEG pattern and process and reactive schizophrenia: A replication. Arch Gen Psychiatry 26:189-192, 1972.

78. Rifkin, A, Levitan, SJ, Galewski, J & Klein, DF: Emotionally unstable character disorder: A follow-up study I: Description of patients and outcome. Biol Psychiatry 4(1):65-79, 1972.

79. Rifkin, A, Levitan, SJ, Galewski, J & Klein, DF: Emotionally unstable character disorder: A follow-up study II: Prediction of outcome. Biol Psychiatry 4(1):81-88, 1972.

80. Struve, FA, Klein, DF & Saraf, KR: Electroencephalographic correlates of suicide ideation and attempts. Arch Gen Psychiatry 27:363-365, 1972.

81. Feldman, S, Klein, DF & Honigfeld, G: The reliability of a decision tree technique applied to psychiatric diagnosis. Biometrics 28:831-840, 1972.

82. Cohen, M & Klein, DF: Social values and drug use among psychiatric patients. Am J Psychiatry 128(8):1017-1019, 1972.

83. Cohen, M & Klein, DF: Age of onset of drug abuse in psychiatric inpatients. Arch Gen Psychiatry 26:(3)266-270, 1972.

84. Quitkin, F, Rifkin, A, Kaplan, J & Klein, DF: Phobic anxiety syndrome complicated by drug dependence and addiction: A treatable form of drug abuse. Arch Gen Psychiatry 27(2):159-162, 1972.

85. Rifkin, A, Quitkin, F, Carrillo, C, Blumberg, AG & Klein,DF: Lithium carbonate in emotionally unstable character disorders. Arch Gen Psychiatry 27:519-523, 1972.

86. Klein, DF: Logic in the use of psychiatric diagnosis. Psychotherapy and Social Science Review 6(11):21-23, 1972.

87. Quitkin, F, Rifkin, A & Klein, DF: Literature review and proposal for lithium prophylaxis studies. J Nat'l Assoc Private Psychiatric Hospitals 4(3)11-15, 1972.

88. Struve, FA, Becka, DR & Klein, DF: The B-Mitten EEG pattern in process and reactive schizophrenia and affective states. Clinical Electroencephalography 3(3):136-144, 1972.

89. Woerner, MG, Pollack, M & Klein, DF: Pregnancy and birth complications in schizophrenics, personality disorders and their siblings. Acta Psychiatrica Scandinavica 49(6):712-721, 1973.

90. Gittelman-Klein, R & Klein, DF: School phobia: Diagnostic considerations in the light of imipramine effects. J Nerv Ment Dis 156(3):199-215, 1973.

91. Rifkin, A, Kurtin, S, Quitkin, F & Klein, DF: Lithium-induced folliculitis. Am J Psychiatry 130(9):1018-1019, 1973.

92. Mendel, JG & Klein, DF: Utilization of the psychiatric consultation service in a large city hospital. Psychosomatics 14(1):57-58, 1973.

93. Quitkin, F, Rifkin, A, McKay, L & Klein, DF: Scapegoating in hospitalized adolescents: A behavioral phenomena associated with schizophrenia with premorbid asociality. Arch Gen Psychiatry 28(5):680-682, 1973.

94. Honigfeld, G & Klein, DF: Hillside Hospital Patient Progress Record: Explorations in clinical management by objective and exception. Evaluation. Special Mono #1:19-22, 1973.

95. Klein, DF & Rosen, B: Premorbid asocial adjustment and response to phenothiazine treatment among schizophrenic inpatients. Arch Gen Psychiatry 29:480-485, 1973.

96. Rifkin, A, Quitkin, F & Klein, DF: Organic brain syndrome during lithium carbonate treatment. Compr Psychiatry 4(3):251-254, 1973.

97. Hoffer, A, Cohen, M & Klein, DF: A classification of patient-peer interaction. Compr Psychiatry 14(3):255-262, 1973.

98. Klein, DF, Honigfeld, G, Feldman, S: Prediction of drug effect in personality disorders. J Nerv Mental Dis 156(3):183-97, 1973.

99. Saraf, KR, Klein, DF, Gittelman, R & Groff, S: Imipramine side effects in children. Psychopharmacologia 37(3):265-274, 1974.

100. Cohen, M & Klein, DF: Post-hospital adjustment of psychiatrically hospitalized drug users. Arch Gen Psychiatry 31:221-227, 1974.

101. Klein, DF: What should the package insert be? Arch Gen Psychiatry 31:735-741, 1974.

102. Woerner, MG & Klein, DF: 14 and 6 per second positive spiking: Developmental and clinical correlates in psychiatric patients and their siblings. J Nerv Ment Dis 159:356-361, 1974.

103. Klein, DF: Endogenomorphic depression: A conceptual and terminological revision. Arch Gen Psychiatry 31:447-451, 1974.

104. Klein, DF: Comment on "On molecular environment of the mind: An orthomolecular theory" by Linus Pauling. Am J Psychiatry 131:1263-1265, 1974.

105. Rifkin, A, Quitkin, F, Blumberg, AG & Klein, DF: The effect of lithium on thyroid functioning: A controlled study. J Psychiatric Res 10:115-120, 1974.

106. Quitkin, F, Gittelman, R, Rifkin, A & Klein, DF: Atypical signs of relapse in affective disorders. Dis Nerv Sys 36:145-146, 1975.

107. Klein, DF, Ross, DC & Feldman, S: Analysis and display of psychopharmacological data. J Psychiatric Res 12:125-147, 1975.

108. Quitkin, F, Rifkin, A, Kaplan, JH & Klein, DF: Treatment of acute schizophrenia with ultra-high dose fluphenazine: A failure at shortening time on a crisis intervention unit. Compr Psychiatry 16(3):279-283, 1975.

109. Rifkin, A, Quitkin, F, Howard, A & Klein, DF: A study of abrupt lithium withdrawal. Psychopharmacologia 44:157-158, 1975.

110. Prichep, L, Cohen, M, Kaplan, J, Karlin, E & Klein, DF: Psychiatric evaluation services to court referred drug users. Am J Drug & Alcohol Abuse 2(2):197:213, 1975.

111. Quitkin, F, Rifkin, A & Klein, DF: Very high dosage vs. standard dosage fluphenazine in schizophrenia: A double-blind study of nonchronic treatment-refractory patients. Arch Gen Psychiatry 32(10):1276-1281, 1975.

112. Rifkin, A, Quitkin, F & Klein, DF: Akinesia: A poorly recognized drug-induced extrapyramidal behavior disorder. Arch Gen Psychiatry 32(5):672-674, 1975.

113. Klein, DF & Gittelman, R: Problems in the diagnosis of minimal brain dysfunction and hyperkinetic syndrome. International J Ment Health 4:45-60, 1975.

114. Gittelman-Klein, R & Klein, DF: Are behavioral and psychometric changes related in methylphenidate treated hyperactive children? International J Ment Health 4:182-198, 1975.

115. Katz, S, Saraf, K, Gittelman-Klein, R & Klein, DF: Clinical pharmacological management of hyperkinetic children. International J Ment Health 4(1-2):157-181, 1975.

116. Klein, DF: Indications for specific treatments of depressions. Psychopharm Bull 11(3):3-13, 1975.

117. Willner, AE, Rabiner, CJ, Wisoff, BG, Hartstein, M, Struve, F.A. & Klein, DF: Analogical reasoning and postoperative outcome: Predictions for patients scheduled for open heart surgery. Arch Gen Psychiatry 33(2):255-259, 1976.

118. Cohen, M, Howard, A, Klein, DF & Newfield, K: Evaluating outcome criteria used in methadone maintenance programs. International J Addictions 11(2):283-294, 1976.

119. Gittelman-Klein, R & Klein, DF: Methylphenidate effects in learning disabilities: Psychometric changes. Arch Gen Psychiatry 33(6):655-668, 1976.

120. Quitkin, F, Rifkin, A & Klein, DF: Prophylaxis of affective disorders: Current status of knowledge. Arch Gen Psychiatry 33(3):337-341, 1976.

121. Struve, FA & Klein, DF: Diagnostic implications of the B-Mitten EEG Pattern: Relationship to primary and secondary affective dysregulation. Biol Psychiatry 11(5):599-611, 1976.

122. Rosen, B, Katzoff, A, Carillo, C & Klein, DF: Clinical effectiveness of "short" vs "1ong" psychiatric hospitalization I: Inpatient results. Arch Gen Psychiatry 33(6):1316-1322, 1976.

123. Struve, FA, Saraf, KR, Arko, RS, Klein, DF & Becka, DR: Electroencephalographic correlates of oral contraceptive use in psychiatric patients. Arch Gen Psychiatry 33(6):741-750, 1976.

124. Quitkin, F, Rifkin, A & Klein, DF: Neurologic soft signs in schizophrenia and character disorders; Organicity in schizophrenia with premorbid asociality and emotionally unstable character disorders. Arch Gen Psychiatry 33(7):845-853, 1976.

125. Gittelman-Klein, R, Klein, DF, Katz, S, Saraf, K & Pollack, E: Comparative effects of methylphenidate and thioridazine in hyperkinetic children. Arch Gen Psychiatry 33(10):1217-1231, 1976.

126. Willner, AE, Rabiner, CJ, Wisoff, BG, Fishman, J, Rosen, B, Hartstein, M & Klein, DF: Analogy tests and psychopathology at follow-up after open heart surgery. Biol Psychiatry 11:687-696, 1976.

127. Gittelman-Klein, R, Klein, DF, Abikoff, H, Katz, S, Gloisten, AC & Katz, W: Relative efficacy of methylphenidate and behavior modification in hyperkinetic children: An interim report. J Abnorm Child Psychiatry 4:361-379, 1976.

128. Leader, M & Klein, DF: Reflections on instituting a computerized psychosocial history in a clinical facility. Compr Psychiatry 18(5):489-495, 1977.

129. Rifkin, A, Quitkin, F, Rabiner, CJ & Klein, DF: Fluphenazine decanoate, fluphenazine hydrochloride given orally, and placebo in remitted schizophrenics I: Relapse rates after one year. Arch Gen Psychiatry 34(1):43-47, 1977.

130. Quitkin, F, Rifkin, A, Gochfeld, L & Klein, DF: Tardive dyskinesia: Are first signs reversible? Am J Psychiatry 134:84-87, 1977.

131. Rifkin, A, Quitkin, F & Klein, DF: Fluphenazine decanoate,oral fluphenazine and placebo in treatment of remitted schizophrenics: II Rating scale data. Arch Gen Psychiatry 34(10):1215-1219, 1977.

132. Abikoff, H, Gittelman-Klein, R & Klein, DF: Validation of a classroom observation code for hyperactive children. J Consult & Clin Psychology 45(5):722-783, 1977.

133. Mattes, J, Rosen, B & Klein, DF: Comparison of the clinical effectiveness of "short" vs. "long" stay psychiatric hospitalization II: Results of a three year post hospital follow-up. J Nerv & Ment Dis 165(6):387-394, 1977.

134. Mattes, JA, Rosen, B, Klein, DF & Millan, D: Comparison of the clinical effectiveness of "short" vs "long" stay psychiatric hospitalization III: Further results of a three year post hospital follow-up. J Nerv & Ment Dis 165(6):395-401, 1977.

135. Klein, DF: Evaluation methodology. J Addictions 12(7):837-849, 1977.

136. Saraf, KR, Klein, DF, Gittelman-Klein, R, Gootman, N & Greenhill, P: EKG effects of imipramine treatment in children. J Acad Child Psych 17(1):60-69, 1978.

137. Rifkin, A, Quitkin, F, Kane, J, Struve, F & Klein, DF: Are prophylactic antiparkinson drugs necessary? A controlled study of procyclidine withdrawal. Arch Gen Psychiatry 35(4):483-489, 1978.

138. Kane, JM, Quitkin, F, Rifkin, A & Klein, DF: Comparison of incidence and severity of extrapyramidal side effects with fluphenazine enanthate and fluphenazine decanoate. Am J Psychiatry 135(12):1539-1542, 1978.

139. Quitkin, F, Rifkin, A & Klein, DF: Imipramine response in deluded depressive patients. Am J Psychiatry 135(7):806-811, 1978.

140. Zitrin, CM, Klein, DF & Woerner, MG: Behavior therapy, supportive psychotherapy, imipramine and phobias. Arch Gen Psychiatry 35(3):307-316, 1978.

141. Quitkin, F, Rifkin, A, Kane, J, Ramos-Lorenzi, JR & Klein, DF: Long-acting oral vs injectable antipsychotic drugs in schizophrenia: A one-year double-blind comparison in multiple episode schizophrenics. Arch Gen Psychiatry 35(7):889-892, 1978.

142. Quitkin, F, Rifkin, A, Kane, J, Ramos-Lorenzi, JR & Klein, DF: Prophylactic effect of lithium and imipramine in unipolar and bipolar II patients: A preliminary report. Am J Psychiatry 135(5):570-572, 1978.

143. Drues, J, Hargreaves, WA, Glick, ID & Klein, DF: Premorbid asocial adjustment and outcome in schizophrenia. J Nerv & Ment Dis 166(12):881-884, 1978.

144. Kane, J, Rifkin, A, Quitkin, F & Klein, DF: Extrapyramidal side effects with lithium treatment. Am J Psychiatry 135(7):851-853 1978.

145. Liebowitz, M, Neutzel, E, Bowser, A & Klein, DF: Phenelzine and delusions of parasitosis: A case report. Am J Psychiatry 135(12):1565-1566, 1978.

146. Ross, DC & Klein, DF: A comparison of analysis of covariance and the O technique as applied to illustrative psychopharmacological data. J Psychiatric Res 15:67-75, 1979.

147. Klein, DF: Comments on "Science and anti-science in confrontation: New responsibilities and new opportunities by Bernard Schoenberg," Man & Medicine 4(2):103-105, 1979 (Columbia University Press).

148. Quitkin, F, Rifkin, A & Klein, DF: Monoamine oxidase inhibitors: A review of antidepressant effectiveness. Arch Gen Psychiatry 36(7):749-760, 1979.

149. Mattes, J, Klein, DF, Millan, D & Rosen, B: Comparison of the clinical effectiveness of "short" vs "long" stay psychiatric hospitalization IV: Predictors of differential benefit. J Nerv & Ment Dis 167(3):175-181, 1979.

150. Kane, J, Rifkin, A, Quitkin, F, Nayak, D, Saraf, K, Ramos-Lorenzi, JR, Klein, DF & Sachar, EJ: Low dose fluphenazine decanoate in maintenance treatment of schizophrenics. Psychiatry Res 1:341-348, 1979.

151. Rifkin, A, Quitkin, F, Kane, J, Klein, DF & Ross, D: The effect of fluphenazine upon social and vocational functioning in remitted schizophrenics. Biol Psychiatry 14(3):499-508, 1979.

152. Liebowitz, MR & Klein, DF: Assessment and treatment of phobic anxiety. J Clin Psychiatry 40(11):486-492, 1979.

153. Dorsey, R, Ayd, F, Cole, J, Klein, DF, Simpson, G, Tupin, J & DiMascio, A: Psychopharmacological screening criteria development project. JAMA 241(10):1021-1031, 1979. Also in: Psychotropic Drugs O.B. Towery & A.B. Brands (Eds.): DHEW # (ADA) Publications, pp. 46-71, 1979.

154. Liebowitz, MR & Klein, DF: Hysteroid dysphoria. Psychiatric Clinics of North America 2(3):555-575, 1979.

155. Zitrin, C, Klein, DF & Woerner, M: Treatment of agoraphobia with group exposure in vivo and imipramine. Arch Gen Psychiatry 37(1):63-72, 1980.

156. Rifkin, A, Saraf, K, Kane, J, Ross, D & Klein, DF: Comparison of trimipramine and imipramine: A controlled study. J Clin Psychiatry 41(4):124-129, 1980.

157. Quitkin, F, Rifkin, A, Tsuang, M, Kane, J & Klein, DF: Can schizophrenia with premorbid asociality be genetically distinguished from the other forms of schizophrenia? Psychiatry Res 2:99-105, 1980.

158. Klein, DF: Psychosocial treatment of schizophrenia or psychosocial help for people with schizophrenia? Schizophrenia Bull 6(1):122-130, 1980.

159. Stewart, JW, Quitkin, F, Fyer, A, Rifkin, A, McGrath, P, Liebowitz, MR, Rosnick, L & Klein, DF: Efficacy of desipramine in endogenomorphically depressed patients. J Affective Disorders 2:165-176, 1980.

160. Klein, DF: A slippery slope. Perspectives in biology & medicine. Part 2, S115-S119, Winter, 1980.

161. Klein, DF: Anxiety reconceptualized. Compr Psychiatry 21(6):411-427, 1980.

162. Abikoff, H, Gittelman, R & Klein, DF: Classroom observation code for hyperactive children: A replication of validity. J Consult & Clin Psychiatry 48(5):555-565, 1980.

163. Klein, DF & Rabkin, JG: Mental health policy; Implications for scientific research on drugs. Annual Science and Technology Report to the Congress, National Science Foundation, Wash. DC, 1980.

164. Liebowitz, MR & Klein, DF: Drug therapy and/or psychotherapy for depression. The Female Patient 6:25-29, 1981.

165. Rifkin, A, Klein, DF, Dillon, D & Levitt, M: Blockade by imipramine or desipramine of panic induced by sodium lactate. Am J Psychiatry 138(5):676-677, 1981.

166. Gorman, JM, Fyer, AF., Gliklich, J, King, D & Klein, DF: Effect of sodium lactate on panic disorder patients with mitral valve prolapse. Am J Psychiatry 138(2):247-249, 1981.

167. Halbreich, U, Weinberg, U, Stewart, JW, Klein, DF & Quitkin, F: An inverse correlation between serum levels of desmethylimipramine and melatonin-like immunoreactivity in DMI-responsive depressives. Psychiatry Res 4:109-113, 1981.

168. Liebowitz, MR & Klein, DF: Interrelationship of hysteroid dysphoria and borderline personality disorder. Psychiatric Clinics of North America 4(l):67-87, 1981.

169. McGrath, PJ, Quitkin, F, Stewart, JW, Liebowitz, MR, Fyer, A, Davies, S & Klein, DF: Novel antidepressants: A clinical trial of mianserin. Psychopharm Bull 17(1):2l-23, 1981.

170. Stewart, JW, Quitkin, F, Liebowitz, MR, McGrath, PJ & Klein, DF: Efficacy of desipramine in mildly depressed patients: A double-blind placebo-controlled trial. Psychopharm Bull 17(1):136-138, 1981.

171. Gorman, JM, Fyer, AJ, Gliklich, J, King, D & Klein, DF: Effect of imipramine on the prolapsed mitral valves of patients with panic disorder. Am J Psychiatry 138(7):977-978, 1981.

172. Liebowitz, MR, Fyer, AJ, McGrath, PJ & Klein, DF: Clonidine treatment of panic disorder. Psychopharm Bull 17(3):122-123, 1981.

173. Liebowitz, MR & Klein, DF: Differential diagnosis and treatment of panic attacks and phobic states. The Annual Review of Medicine 32:583-599, 1981.

174. Liebowitz, MR, Quitkin, FM, Stewart, JW, McGrath, PJ, Harrison, W, Schwartz, D, Rabkin, J, Tricamo, E & Klein, DF: Phenelzine and imipramine in atypical depression. Psychopharm Bull 17(3):159-16l, 1981.

175. Quitkin, FM, Schwartz, DG, Liebowitz, MR, Stewart, JW, McGrath, PJ, Halpern, F, Puig-Antich, J, Tricamo, E, Harrison, W, Sacher, EJ & Klein, DF: Atypical depressives: A preliminary report of antidepressant response and sleep patterns. Psychopharm Bull 18(1):78-80, 1981.

176. Quitkin, F, Kane, JM, Rifkin, A, Ramos-Lorenzi, J, Saraf, K, Howard, A & Klein, DF: Lithium and imipramine in the prophylaxis of unipolar and bipolar II depression: A prospective placebo-controlled comparison. Psychopharm Bull 17(1):142-144, 1981.

177. Kane, JM, Quitkin, F, Rifkin, A, Ramos-Lorenzi, J, Saraf, K, Howard, A & Klein, DF: Prophylactic lithium with and without imipramine for bipolar I patients: A double-blind study. Psychopharm Bull 17(l):144-145, 1981.

178. Wender, PH & Klein, DF: The promise of biological psychiatry. Psychology Today, pp. 25-41, Feb. 1981.

179. Strain, JJ, Liebowitz, MR, Klein, DF: Anxiety and panic attacks in the medically ill. Psychiatric Clinics of North America 4(2):333-50, 1981.

180. Halbreich, U, Sachar, EJ, Asnis, GM, Quitkin, F, Nathan, RS, Halpern, FS & Klein, DF: Growth hormone response to dextroamphetamine in depressed patients and normal subjects. Arch Gen Psychiatry 39(2):189-192, 1982.

181. Frances, A & Klein, DF: DSM-III Case Studies - Anxious, precise, demanding man seeks help soon after marriage. Hosp Comm Psychiatry 33(2):89-90, 1982.

182. Karoum, F, Chuang, L, Eisler, T, Calne, DS, Liebowitz, MR, Quitkin, FM, Klein, DF & Wyatt, RJ: Metabolism of (-) deprenyl to amphetamine and methamphetamine may be responsible for deprenyl's therapeutic benefit: A biochemical assessment. Neurology 32:503-509, 1982.

183. Klein, DF: Panic, separation anxiety, and endorphins. Behvrl and Brn Sciences 3:436-437, 1982.

184. Klein, DF: Editorial. Diagnosis and treatment prescription: Psychiatry's special value. Psychosom 23(8):791-795, 1982.

185. Klein, DF: Medication in the treatment of panic attacks and phobic states. Psychopharm Bull 18(4):85-90, 1982.

186. Liebowitz, MR & Klein, DF: Unresolved issues in the treatment of agoraphobia with panic attacks. Psychopharm Bull 18(4):109-114, 1982.

187. Stewart, JW, Quitkin, FM, McGrath, PJ, Liebowitz, MR & Klein, DF: Efficacy of mianserin in mildly depressed patients. Psychopharm Bull 18(1):68-70, 1982.

188. McGrath, PJ, Quitkin, FM, Blood, D, Liebowitz, MR, Stewart, J, Fyer, AJ & Klein, DF: The effect of mianserin on cardiac conduction: A controlled study. Psychopharm Bull 18(1):71-72, 1982.

189. Gittelman, R, Klein, DF & Feingold, I: Children with reading disorders II: Effects of methylphenidate in combination with reading remediation. J Child Psychol & Psychiatry 24(2):193-212, 1983.

190. Zitrin, CM, Klein, DF, Woerner, MG & Ross, DC: Treatment of Phobias: I. Comparison of imipramine hydrochloride and placebo. Arch Gen Psychiatry 40(2):125-138, 1983.

191. Klein, DF, Zitrin, CM, Woerner, MG & Ross, DC: Treatment of Phobias: II. Behavior therapy and supportive psychotherapy: Are there any specific ingredients? Arch Gen Psychiatry 40(2):139-145, 1983.

192. Stewart, JW, Quitkin, FM, Liebowitz, MR, McGrath, PJ, Harrison, WM & Klein, DF: Efficacy of desipramine in depressed outpatients: Response according to research diagnostic criteria diagnoses and severity of illness. Arch Gen Psychiatry 40(2):202-207, 1983.

193. Liebowitz, MR, Karoum, F, Quitkin, FM, Davies, SO, Stewart, JW, McGrath, PJ, Harrison, W, Schwartz, D, Levitt, M, Linnoila, M, Wyatt, R, Palij, M & Klein, DF: Biochemical effects of deprenyl. Psychopharm Bull 19(3):336-339, 1983.

194. Liebowitz, MR , Fyer, AJ , Appleby, I, Levitt, M, Gorman, J, Dillon, D, Levy, G, Anderson, S, Davies, SO, Palij, M & Klein, DF: Lactate provocation of panic attacks. Psychopharm Bull 19(3):476-478, 1983.

195. Harrison, W, Cooper, TB, Quitkin, FM, Liebowitz, MR, McGrath, PJ, Stewart, JW & Klein, DF: Tyramine sulfate excretion test in depressive illness. Psychopharm Bull 19(3):503-504, 1983.

196. Klein, DF: Is the anti-panic activity of antidepressant medication a reflection of antidepressant effects? Integrative Psychiatry 1(1):26-27, 1983.

197. Kass, F, Charles, E, Klein, DF & Cohen, P: Discordance between the SCL-90 and therapists' psychopathology ratings: Implications for clinical assessment. Arch Gen Psychiatry 40(4):389-393, 1983.

198. Fyer, A, Liebowitz, MR, Gorman, JM, Davies, SO & Klein, DF: Sodium lactate reinfusion of recovered lactate-vulnerable panic disorder patients. 21st Annual Meeting of the ACNP - 1982 Poster Session. Psychopharm Bull 19(4):576-577, 1983.

199. Gorman, JM, Levy, G, Liebowitz, MR, McGrath, P, Appleby, I, Dillon, D, Davies, SO & Klein, DF: Intravenous propranolol during sodium lactate infusion. 21st Annual Meeting of the ACNP - 1982 Poster Session. Psychopharm Bull 19(4):577-578, 1983.

200. Klein, DF: Editorial. The specificity of psychotherapy. Biol Psychiatry 18(10):1105, 1983.

201. Gorman, JM, Levy, G, Liebowitz, MR, McGrath, P, Appleby, IL, Dillon, DJ, Davies, SO & Klein, DF: Effect of acute beta-adrenergic blockade on lactate-induced panic. Arch Gen Psychiatry 40(10):1079-1082, 1983.

202. Liebowitz, MR, Quitkin, FM, Stewart, JW, McGrath, P, Harrison, W, Rabkin, J, Tricamo, E, Markowitz, JS & Klein, DF: Phenelzine vs imipramine in atypical depression: A preliminary report. Arch Gen Psychiatry 41:(7)669-677, 1984.

203. Lindemann, CG, Zitrin, C & Klein, DF: Thyroid dysfunction in phobic patients. Psychosomatics 25(8):603-606, 1984.

204. Harrison, W, Cooper, TB, Stewart, JW, Quitkin, FM, McGrath, PJ, Liebowitz, MR, Rabkin, JR, Markowitz, JS & Klein, DF: The tyramine challenge test as a marker for melancholia. Arch Gen Psychiatry 41(7):681-685, 1984.

205. Liebowitz, MR, Gorman, JM, Fyer, AJ, Dillon, DJ & Klein, DF: Effects of naloxone on patients with panic attacks. Am J Psychiatry 141(8):995-997, 1984.

206. Liebowitz, MR, Quitkin, FM, Stewart, JW, McGrath, PJ, Harrison, W, Rabkin, JG, Tricamo, E, Markowitz, JS & Klein, DF: Psychopharmacological validation of atypical depression. J Clin Psychiatry 45[7 Sect. 2]:22-25, 1984.

207. Gorman, JM, Martinez, JM, Liebowitz, MR, Fyer, AJ & Klein, DF: Hypoglycemia and panic attacks. Am J Psychiatry 141(3):101-102, 1984.

208. Liebowitz, MR, Fyer, AJ, Gorman, JM, Dillon, D., Appleby, IL., Levy, G, Anderson, S, Levitt, M, Palij, M, Davies, SO & Klein, DF: Lactate provocation of panic attacks: I. Clinical & behavioral findings. Arch Gen Psychiatry 41(8):764-770, 1984.

209. McGrath, PJ, Quitkin, FM, Harrison, W & Klein, DF: Treatment of melancholia with tranylcypromine. Am J Psychiatry 141(2):288-289, 1984.

210. Halperin, JM, Gittelman, R, Klein, DF & Rudel, RG: Reading-disabled hyperactive children: A distinct subgroup of attention deficit disorder with hyperactivity? J Abn Child Psychol 12(1):1-14, 1984.

211. Gittelman-Klein, R & Klein, DF: Relationship between separation anxiety and panic and agoraphobic disorders. VII World Congress of Psychiatry. Vienna, Austria, July, 1983. Psychopathology 17(1):56-65, 1984.

212. Fyer, AJ, Gorman, JM, Martinez, J, Levitt, M, Liebowitz, MR & Klein, DF: Sodium lactate infusion, panic attacks and ionized calcium. Biol Psychiatry 19(10):1437-47, 1984.

213. Liebowitz, MR, Gorman, J, Fyer A, Levitt, M, Levy, G, Dillon, D, Appleby, I, Anderson, S, Palij, M, Davies, SO, & Klein, DF: Biological accompaniments of lactate-induced panic. Psychopharm Bull 20(1):43-44, 1984.

214. Klein, DF & Gorman. J: Panic disorders and mitral valve prolapse. J Clin Psychiatry, Monograph Series 2(1):14-17, 1984.

215. Liebowitz, MR, Fyer, AJ, Gorman, JM, Dillon, D, Appleby, IL, Levy, G, Anderson, S, Levitt, M, Palij, M, Davies, SO & Klein, DF: Provocation of panic attacks by sodium lactate infusion. J Clin Psychiatry, Monog Ser 2(1):18-20, 1984.

216. Gorman, JM, Askanazi, J, Liebowitz, MR, Fyer, AJ, Stein, J, Kinney, JM & Klein, DF: Response to hyperventilation in a group of patients with panic disorder. Am J Psychiatry 141(7):857-861, 1984.

217. Klein, DF: Psychopharmacologic treatment of panic disorder. Psychosomatics 25(10):32-36, 1984.

218. Liebowitz, MR, Quitkin, FM, Stewart, JM, McGrath, P, Harrison, W, Rabkin, JG & Klein, DF: Psychopharmacological dissection of nonendogenous depression. Psychopharm Bull 20(3):390-392, 1984.

219. Gorman, JM, Liebowitz, MR, Stein, J, Fyer, AJ & Klein, DF: Insulin levels during lactate infusion. Am J Psychiatry 141(12):1621-1622, 1984.

220. Garakani, H, Zitrin, CM & Klein, DF: Treatment of panic disorder with imipramine alone. Am J Psychiatry 141(3):446-448, 1984.

221. Fyer, AJ, Liebowitz, MR, Gorman, JM, Davies, SO & Klein, DF: Lactate vulnerability of remitted panic patients. Psychiatry Res 14:143-148, 1985.

222. Liebowitz, MR, Gorman, JM, Fyer, AJ, Levitt, M, Dillon, D, Levy, G, Appleby, IL, Anderson, S, Palij, M, Davies, SO & Klein, DF: Lactate provocation of panic attacks: II. Biochemical and physiological findings. Arch Gen Psychiatry 42(7):709-719, 1985.

223. Liebowitz, MR, Gorman, JM, Fyer, AJ & Klein, DF: Social phobia: Review of a neglected anxiety disorder. Arch Gen Psychiatry 42:(7)729-736, 1985.

224. Liebowitz, MR, Fyer, AJ, Gorman, JM, Dillon, D, Davies, S, Stein, J, Cohen, BS & Klein, DF: Specificity of lactate infusions in social phobia vs panic disorders. Am J Psychiatry 142(8):947-949, 1985.

225. Liebowitz, MR, Quitkin, FM, Stewart, JW, McGrath, PJ, Harrison, W, Rabkin, JR, Tricamo, E, Markowitz, JS & Klein, DF: Effect of panic attacks on the treatment of atypical depressives. Psychopharm Bull 21(3):558-562, 1985.

226. Liebowitz, MR, Gorman, J, Fyer, A, Campeas, R, Levin, A, Davies, S & Klein, DF: Psychopharmacological treatment of social phobia. Psychopharm Bull 21(3):610-6l4, 1985.

227. Gorman, J Liebowitz, MR, Fyer, AJ, Levitt, M, Baron, M, Davies, S & Klein, DF: Platelet monoamine oxidase activity in patients with panic disorder. Biol Psychiatry 20(8):852-857, 1985.

228. Gorman, JM, Fyer, AJ, Ross, DC, Cohen, BS, Martinez, JM, Liebowitz, MR & Klein, DF: Normalization of venous pH, pCO, and bicarbonate levels after blockade of panic attacks. Psychiatry Res 14:57-65, 1985.

229. Gorman, JM, Liebowitz, MR, Fyer, AJ, Dillon, D, Davies, SO, & Klein, DF: Lactate infusions in obsessive-compulsive disorder. Am J Psychiatry 142(7):864-866, 1985.

230. Gorman, JM, Dillon, D, Fyer, AJ, Liebowitz, MR & Klein, DF: The lactate infusion model. Psychopharm Bull 21(3):428-433, 1985.

231. Gorman, JM, Liebowitz, MR, Fyer, AJ, Campeas, R & Klein, DF: Treatment of social phobia with atenolol. J Clin Psychopharm 5(5):298-301, 1985.

232. Gittelman, R & Klein, DF: Hillside behavior rating scale (Behavior during testing). Psychopharm Bull 21(4):898-899, 1985.

233. Liebowitz, MR, Gorman, JM, Fyer, AJ, Dillon, D, Levitt, M, & Klein, DF: Possible mechanisms for lactate's induction of panic. Am J Psychiatry 143(4):495-502, 1986.

234. Janowsky, DS, Glick, ID, Lash, L, Mitnick, L, Klein, DF, Goodwin, FK, Hanin, I, Nemeroff, C & Robins, L: Psychobiology and psychopharmacology: Issues in clinical research training. J Clin Psychopharm 6(1):1-7, 1986.

235. Liebowitz, MR, Fyer, AJ, Gorman, JM, Campeas, R, Levin, A, Davies, SO, Goetz, D & Klein, DF: Alprazolam in the treatment of panic disorders. J Clin Psychopharm 6(l):13-20, 1986.

236. Klein, DF & Quitkin, FM: Problems with and promises of monoamine oxidase inhibitors. Psychopharm Bull 22(1):7-1l, 1986.

237. Gorman, JM, Shear, MK, Devereux, RB, King, DL & Klein, DF: Prevalence of mitral valve prolapse in panic disorder: Effect of echocardiographic criteria. Psychosom Med 48(3/4):167-171, 1986.

238. Mannuzza, S, Fyer, AJ, Klein, DF & Endicott, J: Schedule for affective disorders and schizophrenia-lifetime version modified for the study of anxiety disorders (SADS-LA): Rationale and conceptual development. J Psychiatric Res 20(4):317-325, 1986.

239. Kahn, JP, Stevenson, E, Topol, P & Klein, DF: Agitated depression, alprazolam and panic anxiety. Am J Psychiatry 43(9):1172-1173, 1986.

240. Gorman, JM, Cohen, BS, Liebowitz, MR, Fyer, AJ, Ross, D, Davies, SO & Klein, DF: Blood gas changes and hypophosphatemia in lactate-induced panic. Arch Gen Psychiatry 43(11):1067-1075, 1986.

241. Liebowitz, MR, Gorman, JM, Fyer, AJ, Dillon, D & Klein, DF: L'induction pharmacologique des crises de Les nouveaux aspects de l'anxiete, Symposium International. Actualities Medicales Internationales en Psychiatrie, supplement 22:29-34, 1986.

242. Levin, AP, Fyer, AJ, Gorman, JM, Liebowitz, MR & Klein, DF: Troubles paniques. Les nouveaux aspects de l'anxiete, Symposium International. Actualities Medicales Internationales en Psychiatrie, supplement 22:90-96, 1986.

243. Liebowitz, MR, Fyer, AJ, Gorman, JM & Klein, DF: Recent developments in the understanding and pharmacotherapy of panic attacks. Psychopharm Bull, 22(3):792-796, 1986.

244. Gorman, JM, Liebowitz, MR, Fyer, AJ & Klein, DF: Possible respiratory abnormalities in panic disorder. Psychopharm Bull, 22(3):797-801, 1986.

245. Rabkin, JG, Markowitz, JS, Stewart, J, McGrath, P, Harrison, W, Quitkin, FM & Klein, DF: How blind is blind? Assessment of patient and doctor medication guesses in a placebo-controlled trial of imipramine and phenelzine. Psychiatric Res 19:75-86, 1986.

246. Gorman, JM, Liebowitz, MR, Fyer, AJ, Goetz, D, Campeas, R, Fyer, MR, Davies, SO & Klein, DF: An open trial of fluoxetine in the treatment of panic attacks. J Clin Psychopharm 7(5):329-332, 1987.

247. Kahn, JP, Drusin, RE & Klein, DF: Idiopathic cardiomyopathy and panic disorder: Clinical association in cardiac transplant candidates. Am J Psychiatry 44(10):1327-1330, 1987.

248. Levin, AP, Doran, AR, Liebowitz, MR, Fyer, AJ, Gorman, JM, Klein, DF & Paul, SM: Pituitary adrenocortical unresponsiveness in lactate-induced panic. Psychiatric Res 21(1):23-32, 1987.

249. Fyer, AJ, Liebowitz, MR, Gorman, JM, Campeas, R, Levin, A, Davies, SO, Goetz, D & Klein, DF: Discontinuation of alprazolam treatment in panic patients. Am J Psychiatry 144(3):303-308, 1987.

250. Dillon, DJ, Gorman, JM, Liebowitz, MR, Fyer, AJ & Klein, DF: The measurement of lactate-induced panic and anxiety. Psychiatric Res 20:97-105, 1987.

251. Klein, DF, Ross, DC & Cohen, P: Panic and avoidance in agoraphobia: Application of PATH analysis to treatment studies. Arch Gen Psychiatry 44(3):377-385, 1987.

252. Klein, DF & Gorman, JM: A model of panic and agoraphobic development. Acta Psychiatr Scand, 76 (suppl 335):87-95, 1987.

253. Gorman, JM, Liebowitz, MR, Dillon, D, Fyer, AJ, Cohen, BS, & Klein, DF: Antipanic drug effects during lactate infusion in lactate-refractory panic patients. Psychiatric Res 21:205-212, 1987.

254. Gorman, JM, Davies, M, Steinman, R, Liebowitz, MR, Fyer, AJ, Coromilas, J & Klein, DF: An objective marker of lactate-induced panic. Psychiatric Res 22:341-348, 1987.

255. Papp, LA, Klein, DF & Gorman, JM: Commentary: Hyperventilation, anxiety, and panic. Integrative Psychiatry 5:289-291, 1987.

256. Fyer, MR, Klein, DF, Liebowitz, MR, Fyer, AJ & Gorman, JM: CO2 challenge of patients with panic disorder. Am J Psychiatry 144(8):1080-1082, 1987.

257. McGrath, PJ, Stewart, JW, Markowitz, J, Liebowitz, MR, Gorman, JM, Quitkin, FM & Klein, DF: Lactate provocation of panic attacks in depressed outpatients. Psychiatric Res 25:41-47, 1988.

258. Klein, DF: Cybernetics, activation, and drug effects. Acta Psychiatrica Scandinavica, The Netherlands, 77(341): 126-137, 1988.

259. Liebowitz, MR, Quitkin, FM, Stewart, JW, McGrath, PJ, Harrison, WM, Markowitz, JS, Rabkin, JG, Tricamo, E, Goetz, DM & Klein, DF: Antidepressant specificity in atypical depression. Arch Gen Psychiatry 45(2):129-137, 1988.

260. Ross, DC & Klein, DF: Group matching: Is this a research technique to be avoided? Educational and Psychological Measurement 48:281-295, 1988.

261. Gorman, JM, Goetz, RR, Martinez, J, Uy, J, Ross, D, Fyer, AJ, Liebowitz, MR & Klein, DF: Hyperventilation occurs during lactate-induced panic. J Anxiety Disorders 2:193-202, 1988.

262. Wager, SG & Klein, DF: Drug therapy strategies for treatment resistant depression. Psychopharm Bull 24(1):69-74, 1988.

263. Klein, DF & Klein, HM: The status of panic disorder. Current Opinion in Psychiatry 1:177-183, 1988.

264. Gorman, JM, Goetz, RR, Fyer, MR, King, DL, Fyer, AJ, Liebowitz, MR & Klein, DF: The mitral valve prolapse-panic disorder connection. Psychosomatic Medicine 50(2):114-l22, 1988.

265. Klein, RG, Landa, B, Mattes, JA & Klein, DF: Methylphenidate and growth in hyperactive children: A controlled withdrawal study. Arch Gen Psychiatry 45(12):1127-1130, 1988.

266. Quitkin, FM, Stewart, JW, McGrath, PJ, Liebowitz, MR, Harrison, WM, Tricamo, E, Klein, DF, Rabkin, JG, Markowitz, JS & Wager, SG: Phenelzine versus imipramine in the treatment of probable atypical depression: Defining syndrome boundaries of selective MAOI responders. Am J Psychiatry 145(3):306-31l, 1988.

267. Kahn, JP, Puertollano, MA, Schane, MD & Klein, DF: Adjunctive alprazolam for schizophrenia with panic anxiety: Clinical observation and pathogenetic implications. Am J Psychiatry 145(6):742-744, 1988.

268. Stewart, JW, Quitkin, FM, McGrath, PJ, Rabkin, JG, Markowitz, J, Tricamo, E & Klein, DF: Social functioning in chronic depression: Effect of six-weeks of antidepressant treatment. Psychiatric Res 25:213-222, 1988.

269. Papp, LA, Gorman, JM, Liebowitz, MR, Fyer, AJ, Cohen, B& Klein, DF: Epinephrine infusions in patients with social phobia. Am J Psychiatry l45(6):733-736, 1988.

270. Klein, DF: Rheostat and cybernetic issues. Comments on "The Current Status of the Dopamine Hypothesis of Schizophrenia". Neuropsychopharmacology 1(3):187-188, 1988.

271. Liebowitz, MR, Fyer, AJ, Gorman, JM, Campeas, RB, Sandberg, DP, Hollander, E, Papp, LA & Klein, DF: Tricyclic therapy of the DSM-III anxiety disorders: A review with implications for further research. J Psychiatric Res 22(1):7-31, 1988.

272. Fyer, AJ, Liebowitz, MR, Gorman, JM, Campeas , R, Levin, A, Sandberg, D, Fyer, M, Hollander, E, Papp, LA, Goetz, D & Klein, DF: Effects of clonidine on alprazolam discontinuation in panic patients: A pilot study. J Clin Psychopharm 8(4):270-274, 1988.

273. Gewirtz, GR, Malaspina, D, Hatterer, JA, Feureisen, S, Klein, DF & Gorman, JM: Occult thyroid dysfunction in patients with refractory depression. Am J Psychiatry 145(8):1012-1014, 1988.

274. McGrath, PJ, Cooper, TB, Quitkin, FM & Klein, DF: Effects of imipramine and phenelzine on plasma phenylethylamine (PEA) levels. Psychiatric Res 26:239, 1988.

275. Gorman, JM, Fyer, MR, Goetz, R, Askanazi, J, Liebowitz, MR, Fyer, AJ, Kinney, J & Klein, DF: Ventilatory physiology of patients with panic disorder. Arch Gen Psychiatry 45(1):31-39, 1988.

276. Mannuzza, S, Fyer, AJ, Martin, LY, Gallops, MS, Endicott, J, Gorman, JM, Liebowitz, MR & Klein, DF: Reliability of Anxiety Assessment: I. Diagnostic agreement. Arch Gen Psychiatry 46(12):1093-1101, 1989.

277. Fyer, AJ, Mannuzza, S, Martin, LY, Gallops, MS, Endicott, J, Schleyer, B, Gorman, JM, Liebowitz, MR & Klein, DF: Reliability of Anxiety Assessment: II. Symptom agreement. Arch Gen Psychiatry 46(12):1102-1110, 1989.

278. Hollander, E, Liebowitz, MR, Winchel, RW, Klumker, A & Klein, DF: Treatment of body-dysmorphic disorder with serotonin reuptake blockers. Am J Psychiatry 146(6):768-770, 1989.

279. Papp, LA, Goetz, R, Cole, R, Klein, DF, Jordan, F, Liebowitz, MR, Fyer, AJ, Hollander, E & Gorman, JM: Hypersensitivity to carbon dioxide in panic disorder. Am J Psychiatry 146(6):779-781, 1989.

280. Hollander, E, Liebowitz, MR, Gorman, JM, Cohen, B, Fyer, AJ, & Klein, DF: Cortisol and sodium lactate-induced panic. Arch Gen Psychiatry 46(2):135-140, 1989.

281. Klein, DF & Klein, HM: The substantive effect of variations in panic measurement and agoraphobia definition. J of Anxiety Disorders 3:45-56, 1989.

282. Gorman, JM, Battista, D, Goetz, RR, Dillon, DJ, Liebowitz, MR, Fyer, AJ, Kahn, JP, Sandberg, D & Klein, DF: A comparison of sodium bicarbonate and sodium lactate infusion in the induction of panic attacks. Arch Gen Psychiatry 46(2):145-150, 1989.

283. Nunes, EV, Quitkin, FM & Klein, DF: Psychiatric diagnosis in cocaine abuse. Psychiatric Res 28(1):105-114, 1989.

284. Quitkin, FM, McGrath, PJ, Stewart, JW, Harrison, W, Wager, SG, Nunes, E, Rabkin, JG, Tricamo, E, Markowitz, J & Klein, DF: Phenelzine and imipramine in mood reactive depressives: Further delineation of the syndrome of atypical depression. Arch Gen Psychiatry 46(9):787-793, 1989.

285. Hollander, E, Liebowitz, MR, Cohen, B, Gorman, JM, Fyer, AJ, Papp, LA & Klein, DF: Prolactin and sodium lactate-induced panic. Psychiatric Res 28(2):181-191, 1989.

286. Klein, DF & Klein, HM: The utility of the panic disorder concept. European Archives of Psychiatry & Neurological Sciences 238:268-279, 1989.

287. Papp, LA, Martinez, JM, Klein, DF, Ross, D, Liebowitz, MR, Fyer, AJ, Hollander, E & Gorman, JM: Arterial blood gas changes in panic disorder and lactate-induced panic. Psychiatric Res 28:171-180, 1989.

288. Goetz, RR, Gorman, JM, Dillon, DJ, Papp, LA, Hollander, E, Fyer, AJ, Liebowitz, MR & Klein, DF: Do panic disorder patients indiscriminately endorse somatic complaints? Psychiatric Res 29(2):207-213, 1989.

289. Klein, DF: Schizophrenia and bipolar affective disorders: Likenesses and differences. Grand Rounds presentation, Hillside Hospital, Glen Oaks, NY, February 17, 1988. Hillside J Clin Psychiatry 11(l):3-15, 1989.

290. Schneier, FR, Martin, LY, Liebowitz, MR, Gorman, JM, Klein, DF & Fyer, AJ: Alcohol abuse in social phobia. J Anxiety Disorders 3:15-23, 1989.

291. Hollander, E, Nunes, E, DeCaria, C, Quitkin, F, Cooper, T, Wager, S & Klein, DF: Dopaminergic sensitivity and cocaine abuse: Response to apomorphine. Psychiatric Res 33:161-169, 1990.

292. Klein, DF: Pharmacotherapy of obsessive compulsive disorder. L'Encephale XVI:331-4, 1990.

293. Kahn, JP, Gorman, JM, King, DL, Fyer, AJ, Liebowitz, MR, & Klein, DF: Cardiac left ventricular and chamber dilatation in panic disorder patients: Implications for idiopathic dilated cardiomyopathy. Psychiatric Res 32(1):55-61, 1990.

294. Fyer, AJ, Mannuzza, S, Gallops, MS, Martin, LY, Aaronson, C, Gorman, JM, Liebowitz, MR & Klein, DF: Familial transmission of simple phobias and fears: A preliminary report. Arch Gen Psychiatry 47(3):252-256, 1990.

295. Hollander, E, DeCaria, C, Schneier, F, Schneier, H, Liebowitz, MR & Klein, DF: Fenfluramine augmentation of serotonin reuptake blockade antiobsessional treatment. J Clin Psychiatry 51(3):119-123, 1990.

296. Schneier, F, Liebowitz, MR, Fairbanks, J, Hollander, E, Campeas, R & Klein, DF: Fluoxetine in panic disorder. J Clin Psychopharm 10(2):119-121, 1990.

297. Rabkin, JG, McGrath, PJ, Quitkin, FM, Tricamo, E, Stewart, JW & Klein, DF: Effects of pill giving on maintenance of placebo response in patients with chronic mild depression. Am J Psychiatry 147(12):1622-1626, 1990.

298. Klein, DF: Psychotropic drug development: Challenge and Promise (Editorial) Biol Psychiatry 27:1061-1064, 1990.

299. Quitkin, FM, McGrath, PJ, Stewart, JW, Harrison, W, Tricamo, E, Wager, SG, Ocepek-Welikson, K, Nunes, E, Rabkin, JG & Klein, DF: Atypical depression, panic attacks, and response to imipramine and phenelzine: A replication. Arch Gen Psychiatry 47(10):935-941, 1990.

300. Hollander, E, Liebowitz, MR, DeCaria, C, Fairbanks, J, Fallon, B & Klein, DF: Treatment of depersonalization with serotonin reuptake blockers. J Clin Psychopharm 10(3):200-203, 1990.

301. Gorman, JM, Goetz, RR, Dillon, D, Liebowitz, MR, Fyer, AJ, Davies, S & Klein, DF: Sodium d-lactate infusion of panic disorder patients. Neuropsychopharmacology 3(3):181-189, 1990.

302. Mannuzza, S, Fyer, AJ, Liebowitz, MR & Klein, DF: Delineating the boundaries of social phobia: Its relationship to panic disorder and agoraphobia. J Anxiety Disorders 4:41-59, 1990.

303. Hollander, E, DeCaria, CM, Aronowitz, B, Klein, DF, Liebowitz, MR & Shaffer, D: A pilot follow-up study of childhood soft-signs and the development of adult psychopathology. J Neuropsych & Clin Neurosciences 3(2):186-189, 1991.

304. Hollander, E, DeCaria, C, Nitescu, A, Cooper, T, Stover, B, Gully, R, Klein, DF & Liebowitz, MR: Noradrenergic function in obsessive compulsive disorder: Behavioral and neuroendocrine responses to clonidine and comparison to healthy controls. Psychiatry Res 37:161-177, 1991.

305. Hollander, E, Mullen, L, DeCaria, C, Skodol, A, Schneier, F, Liebowitz, MR & Klein, DF: Obsessive-compulsive disorder, depression, and fluoxetine. J Clin Psychiatry 52(10):418-422, 1991.

306. Quitkin, FM, Rabkin, JG, Stewart, JW, McGrath, PJ, Harrison, W, Ross, DC, Tricamo, E, Fleiss, J, Markowitz, J & Klein, DF: Heterogeneity of clinical response during placebo treatment. Am J Psychiatry 148(2):193-196, 1991.

307. Quitkin, FM, McGrath, PJ, Rabkin, JG, Stewart, JW, Harrison,W, Ross, DC, Tricamo, E, Fleiss, J, Markowitz, J & Klein, DF: Different types of placebo response in patients receiving antidepressants. Am J Psychiatry 148(2):197-203, 1991.

308. Klein, DF: Improvement of phase III psychotropic drug trials by intensive phase II work. Neuropsychopharmacology 4(4):251-258, 1991.

309. Klein, DF: Reply to commentaries: Improvement of phase III psychotropic drug trials by intensive phase II work. Neuropsychopharmacology 4(4):269-271, 1991.

310. Hollander, E, DeCaria, C, Nitescu, A, Gulley, R, Cooper, TB, Gorman, JM, Klein, DF & Liebowitz, MR: Effects of chronic fluoxetine treatment on behavioral and neuroendocrine response to m-CPP in obsessive-compulsive disorder. Psychiatry Res 36:1-17, 1991.

311. Vinar, O, Klein, DF, Potter, WZ & Gause, EM: A survey of psychotropic medications not available in the United States. Neuropsychopharmacology 5(4):201-217, 1991.

312. Quitkin, FM, Harrison, W, Stewart, JW, McGrath, PJ, Tricamo, E, Ocepek-Welikson, K, Rabkin, JG, Wager, SG, Nunes, E & Klein, DF: Response to phenelzine and imipramine in placebo responders with atypical depression: A new application of the crossover design. Arch Gen Psychiatry 48(4):319-323, 1991.

313. Klein, DF: Scientific fraud and misconduct. (Editorial) J Clin Psychopharm 11(6):337-338, 1991.

314. Klein, DF: Commentary on "Psychology and Pharmacology in the Treatment of Anxiety Disorders: Cooperation or Confrontation?" by H.C. Middleton, M.D. J of Pharmacol 5(4):299-300, 1991.

315. Schneier, FR, Fyer, AJ, Martin, LY, Ross, D, Mannuzza, S, Liebowitz, MR, Gorman, JM & Klein, DF: A comparison of phobic subtypes within panic disorder. J Anxiety Disorders 5:65-75, 1991.

316. Shear, MK, Fyer, AJ, Ball, G, Josephson, S, Fitzpatrick, M, Gitlin, B, Frances, A, Gorman, J, Liebowitz, M and Klein, DF: Vulnerability to sodium lactate in panic disorder patients given cognitive-behavioral therapy. Am J Psychiatry 148(6):795-797, 1991.

317. Liebowitz, MR, Schneier, F, Campeas, R, Hollander, E, Hatterer, J, Fyer, AJ, Gorman, J, Papp, L, Davies, S, Gully, R & Klein, DF: Phenelzine vs. atenolol in social phobia: A placebo controlled comparison. Arch Gen Psychiatry 49(4):290-300, 1992.

318. Mannuzza, S, Fyer, AJ, Endicott, J, Gallops, MS, Martin, LY, Reich, T & Klein, DF: An extension of the acquaintanceship procedure in family studies of mental disorder. J Psychiatric Res 26(1):45-57, 1992.

319. Hollander, E, DeCaria, C, Nitescu, A, Gully, R, Suckow, RF, Cooper, TB, Gorman, JM, Klein, DF & Liebowitz, MR: Serotonergic function in obsessive compulsive disorder: Behavioral and neuroendocrine responses to oral m-CPP and fenfluramine in patients and healthy volunteers. Arch Gen Psychiatry 49(1):21-28, 1992.

320. Stewart, JW, Quitkin, FM & Klein, DF: The pharmacotherapy of minor depression. Am J Psychotherapy XLVI(1):23-36, 1992.

321. Coplan, JD, Liebowitz, MR, Gorman, JM, Fyer, AJ, Dillon, DJ, Campeas, RB, Davies, SO, Martinez, J & Klein, DF: Noradrenergic function in panic disorder effects of intravenous clonidine pretreatment on lactate induced panic. Biol Psychiatry 31:135-146, 1992.

322. Klein, DF, Mannuzza, S, Chapman, T & Fyer, AJ: Child panic revisited. J Am Acad of Child & Adolesc Psychiatry 31(1):112-116, 1992.

323. Coplan, JD, Gorman, JM & Klein, DF: Serotonin related functions in panic-anxiety; A critical overview. Neuropsychopharmacology 6(3):189-200, 1992.

324. McGrath, PJ, Stewart, JW, Harrison, WM, Ocepek-Welikson, K, Rabkin, JG, Nunes, E, Wager, S, Tricamo, E, Quitkin, FM & Klein, DF: Predictive value of symptoms of atypical depression for differential drug treatment outcome. J Clin Psychopharm 12(3):197-202, 1992.

325. Stein, JM, Papp, LA, Klein, DF, Cohen, S, Simon, J, Ross, D, Martinez, J & Gorman, JM: Exercise tolerance in panic disorder patients. Biol Psychiatry 32:281-287, 1992.

326. Klein, DF & Klein, RG: Methodologic issues in maintenance therapy clinical trials; A commentary. International J of Methods in Psych Res 2(3):107-109, 1992.

327. Mannuzza, S, Aronowitz, B, Chapman, T, Klein, DF & Fyer, AJ: Panic disorder and suicide attempts. J Anxiety Disorders 6:261-274, 1992.

328. Stein, DJ, Hollander, E, Anthony, D, Schneier, FR, Fallon, BA, Liebowitz, MR & Klein, DF: Serotonergic medications for sexual obsessions, sexual addictions and paraphilias. J Clin Psychiatry 53:267-271, 1992.

329. Klein, DF: Commentary on "Panic disorder-old wine in new bottles" by Leo E. Hollister. Integrative Psychiatry 8(2):85-86, 1992.

330. Fyer, AJ, Mannuzza, S, Chapman, T, Liebowitz, MR & Klein, DF: A direct interview family study of social phobia. Arch Gen Psychiatry 50(4):286-293, 1993.

331. Goetz, RR, Klein, DF, Gully, DJ, Kahn, J, Liebowitz, MR, Fyer, AJ, & Gorman, JM: Panic attacks during placebo procedures in the laboratory: Physiology and symptomatology. Arch Gen Psychiatry 50(4):280-285, 1993.

332. McGrath, PJ, Stewart, JW, Nunes, E, Ocepek-Welikson, K, Rabkin, JG, Quitkin, FM & Klein, DF: A double-blind crossover trial of imipramine and phenelzine for outpatients with treatment-refractory depression. Am J Psychiatry 150(1):118-123, 1993.

333. Klein, DF & Ross, DC: Reanalysis of the National Institute of Mental Health Treatment of Depression Collaborative Research Program General Effectiveness Report. Neuropsychopharmacology 8(3):241-252, 1993.

334. Klein, DF: The utility of the super-normal control group in psychiatric genetics. Psychiatric Genetics 3(1):17-19, 1993.

335. Klein, DF: False suffocation alarms, spontaneous panics, and related conditions; An integrative hypothesis. Arch Gen Psychiatry 50(4):306-317, 1993.

336. Quitkin, FM, Stewart, JW, McGrath, PJ, Nunes, E, Ocepek-Welikson, K, Tricamo, E, Rabkin, J, Ross, D & Klein, DF: Loss of drug effects during continuation therapy. Am J Psychiatry 150(4):562-565, 1993.

337. Quitkin, FM, Stewart, JW, McGrath, PJ, Nunes, E, Ocepek-Welikson, K, Tricamo, E, Rabkin, JG & Klein, DF: Further evidence that a placebo response to antidepressants can be identified. Am J Psychiatry 150(4):566-570, 1993.

338. Chapman, TF, Fyer, AJ, Mannuzza, S & Klein, DF: A comparison of treated and untreated simple phobia. Am J Psychiatry 150:816-818, 1993.

339. Hollander, E, DeCaria, CM, Saoud, JB, Klein, DF & Liebowitz, MR: A pilot study of biological predictors of treatment outcome in obsessive-compulsive disorder. Biol Psychiatry 33:747-749, 1993.

340. Klein, DF: Clinical psychopharmacologic practice: The need for developing a research base. Arch Gen Psychiatry 50(6):491-494, 1993.

341. Papp, LA, Klein, DF, Martinez, J, Schneier, F, Cole, R, Liebowitz, MR, Hollander, E, Fyer, AJ, Jordan, F & Gorman, JM: Diagnostic and substance specificity of carbon-dioxide-induced panic. Am J Psychiatry 150(2):250-257, 1993.

342. Papp, LA, Klein, DF & Gorman, JM: Carbon dioxide hypersensitivity, hyperventilation and panic disorder. Am J Psychiatry 150(8):1149-1157, 1993.

343. Klein, DF: Mixed anxiety depression: For and against. (Proceedings of the Eighth International Thematic Meeting Paris, November 27, 1992.) L'Encephale XIX:493-495, 1993.

344. Hollander, E, Cohen, LJ, DeCaria, C, Saoud, JB, Stein, DF, Cooper, TB, Islam, MN, Liebowitz, MR & Klein, DF: Timing of neuroendocrine responses and effect of m-CPP and fenfluramine plasma levels in OCD. Biol Psychiatry 34:407-413, 1993.

345. Mannuzza, S, Fyer, AJ & Klein, DF: Assessing psychopathology. International J of Methods in Psych Res 3:157-165, 1993.

346. Fallon, BA, Nields, JA, Parsons, B, Liebowitz, MR & Klein, DF: Psychiatric manifestations of Lyme Borreliosis. J Clin Psychiatry 54(7):263-268, 1993.

347. Quitkin, FM, Stewart, JW, McGrath, P.J., Tricamo, E., Rabkin, JG, Ocepek-Welikson, K, Nunes, E, Harrison, W & Klein, DF: Columbia atypical depression: A sub-group of depressives with better response to MAOI than to tricyclic antidepressants or placebo. Br J Psychiatry 163(Suppl.21):30-34, 1993.

348. Klein, DF: Should the government assure scientific integrity? Academic Medicine 68(9, Suppl.):S56-S59, 1993.

349. Fallon, BF, Liebowitz, MR, Salman, E, Schneier, F, Jusino, C, Hollander, E & Klein, DF: Fluoxetine for hypochondriacal patients without major depression. J Clin Psychopharm 13(6):438-441, 1993.

350. Gorman, JM, Papp, LA, Coplan, J, Martinez, J, Liebowitz, MR & Klein, DF: The effect of acetazolamide on ventilation in panic disorder patients. Am J Psychiatry 150(10):1480-1484, 1993.

351. Klein, DF: Identified placebo treatment? Neuropsychopharmacology 10(4):271-272, 1994.

352. Klein, DF: The utility of guidelines and algorithms for practice. Psychiatric Annals 24(7):362-367, 1994.

353. Klein, DF: The treatment of atypical depression. European Psychiatry 8(5):251-255, 1993.

354. Stein, DJ, Hollander, E, Chan, S, DeCaria, CM, Hilal, S, Liebowitz, MR, Klein, DF: Computed tomography and neurological soft signs in obsessive-compulsive disorder. Psych Res 50 (3):143-150, 1993.

355. Lipsitz, JD, Martin, LY, Mannuzza, S, Chapman, TF, Liebowitz, MR, Klein, DF & Fyer, AJ: Childhood separation anxiety disorder in patients with adult anxiety disorders. Am J Psychiatry 151(6):927-929, 1994.

356. Klein, DF: Testing the suffocation false alarm theory of panic disorder. Anxiety 1:1-7, 1994.

357. Goetz, RR, Klein, DF & Gorman, JM: Consistencies between recalled panic and lactate induced panic. Anxiety 1:31-36, 1994.

358. Chapman, T, Fyer, AJ, Mannuzza & Klein, DF: Effects of informant mental disorder on psychiatric family history data. Am J Psychiatry 151(4): 574-579, 1994.

359. Pine, DS, Weese-Mayer, DE, Silvestri, JM, Davies, M, Whitaker, A & Klein, DF: Anxiety and Congenital Central Hypoventilation Syndrome. Am J Psychiatry 151(6): 864-870, 1994.

360. Stein, DJ, Hollander, E & Klein, DF: Biological markers of depression and anxiety. Medicographia 16(1): 18-21, 1994.

361. Gorman, JM, Papp, LA, Coplan, JD, Martinez, JM, Lennon, S, Goetz, RR, Ross, D & Klein, DF: Anxiogenic effects of CO2 and hyperventilation in patients with panic disorder. Am J Psychiatry 151(4): 547-553, 1994.

362. Liebowitz, MR, Salman, E, Jusino, CM, Garfinkel, R, Street, L, Cardenas, D, Silvestre, J, Fyer, AJ, Carrasco, JL, Davies, S, Guarnaccia, P & Klein, DF: Ataque de nervios and panic disorder. Am J Psychiatry 151(6): 871-875, 1994.

363. Klein, DF: Pregnancy and panic disorder (Commentary). J Clin Psychiatry 55(7):293-294, 1994.

364. Mannuzza, S, Schneier, FR, Chapman, TF, Liebowitz, MR, Klein, DF & Fyer, AJ: Generalized social phobia: Reliability and validity. Arch Gen Psychiatry 52:230-237, 1995.

365. Papp, LA, Martinez, JM, Klein, DF, Coplan, J & Gorman, JM: Rebreathing tests in panic disorder. Biol Psychiatry 38(4): 240-245, 1995.

366. Nunes, EV, McGrath, PJ, Quitkin, FM, Ocepek-Welikson, K, Stewart, JW, Koenig, T, Wager, S & Klein, DF: Imipramine treatment of cocaine abuse: Possible boundaries of efficacy. Drug and Alcohol Dependence 39:185-195, 1995.

367. Fyer, AJ, Mannuzza, S, Chapman, TF, Martin, LY & Klein, DF: Specificity in familial aggregation of phobic disorders. Arch Gen Psychiatry 52(7): 564-573, 1995.

368. Klein, DF, Skrobala, A & Garfinkel, RS: Preliminary look at the effects of pregnancy on the course of panic disorder. Anxiety 1(5): 227-232, 1995.

369. Mannuzza, S, Chapman, TF, Klein, DF & Fyer, AJ: Familial transmission of panic disorder: Effect of major depression comorbidity. Anxiety 1:180-185, 1994/1995.

370. Klein, DF: Improving medication and legislation by controlled experimentation. Psychiatric Annals 25(1):67-69, 1995.

371. Klein, DF: Psychopharmacological practice and health reform. Psychiatric Annals 25(2):79-83, 1995.

372. Klein, DF. Response to critique of suffocation alarm theory. Anxiety 1(3):145-148, 1995.

373. Klein, DF: Treatment of panic disorder, agoraphobia and social phobia. Clinical Neuropharmacology 18 (suppl. 2):S45-S51, 1995.

374. Resschke, AH, Mannuzza, S, Chapman, TF, Lipsitz, JD, Liebowitz, MR, Gorman, JM, Klein, DF, Fyer, AJ: Sodium lactate response and familial risk for panic disorder. Am J Psychiatry 152(2):277-279, 1995.

375. Glick, ID, Lecrubier, Y, Montgomery, SA, Vinar, O & Klein, DF: Efficacious and safe psychotropics not available in the United States. Psychiatric Annals 26:354-361, 1996.

376. Klein, DF: Response to Rothman and Michels on placebo-controlled clinical trials. Psychiatric Annals 25(7):401-403, 1995.

377. Marshall, RD & Klein, DF: Pharmacotherapy in the treatment of posttraumatic stress disorder. Psychiatric Annals 25(10):588-597, 1995.

378. Papp, LP, Welkowitz, LA, Martinez, JM, Klein, DF, Browne, S & Gorman, JM. Instructional set does not alter outcome of respiratory challenges in panic disorder. Biological Psychiatry 38(12):826-830, 1995.

379. Klein, DF. What's new in DSM-IV? Psychiatric Annals 25(8):461-474, 1995.

380. Klein, DF: Counterevidence from psychopharmacology, psychopathology, and psychobiology. Behav Brain Sci 18(2):302-3, 1995.

381. Klein, DF: Forword: Controversies and conventions in panic disorder: questions and answers in recognition and treatment. European Psychiatry 10 (suppl. 2):55s, 1995.

382. Klein, DF: Recognising panic disorder. European Psychiatry 10 (suppl. 2):61s-63s, 1995.

383. Liebowitz, MR, Coplan, JD, Martinez, J, Fyer, AJ, Dillon, DJ, Campeas, RB, Davies, SO, Gorman, JM, & Klein, DF: Effects of intravenous diazepam pretreatment on lactate-induced panic. Psychiatry Research 58:127-138, 1995.

384. Martinez, JM, Papp, LA, Anderson, DE, Mueller, CM, Klein, DF, Coplan, JD & Gorman, JM. Ambulatory monitoring of respiration in anxiety. Anxiety 2:296-302, 1996.

385. Quitkin, FM, McGrath, PJ, Stewart, JW, Ocepek-Welikson, K, Taylor, BP, Nunes, E, Deliyannides, D, Agosti, V, Donovan, SJ, Petkova, E & Klein, DF: Chronological milestones to guide drug change: When should clinicians switch antidepressants? Arch Gen Psychiatry 53(9):785-792, 1996.

386. Schwartz, GE, Goetz, RR, Klein, DF, Endicott, J & Gorman, JM: Tidal volume of respiration and "sighing" as indicators of breathing irregularities in panic disorder patients. Anxiety 2/3:145-148, 1996.

387. Quitkin, FM, McGrath, PJ, Stewart, JW, Taylor, BP & Klein, DF: Can the effects of antidepressants be observed in the first two weeks of treatment? Neuropsychopharmacology 15(4):390-394, 1996.

388. Fyer, AJ, Mannuzza, S, Chapman, TF, Lipsitz, J, Martin, LY& Klein, DF: Panic disorder and social phobia: Effects of comorbidity on familial transmission. Anxiety 2:173-178, 1996.

389. Klein, DF: Preventing hung juries about therapy studies. J Consulting and Clinical Psychology 64(1):81-87, 1996.

390. Goetz, RR, Klein, DF & Gorman, JM: Symptoms essential to the experience of sodium lactate-induced panic. Neuropsychopharmacology 14(5):355-366, 1996.

391. Klein, DF: Discussion of "Methodological Controversies in the Treatment of Panic Disorder" by McNally. Behaviour Research and Therapy 34(11/12):849-853, 1996.

392. Klein, DF: Critiquing McNally's reply. Behaviour Research and Therapy 34(11/12):859-863, 1996.

393. Klein, DF: Comments on "Integrity and Misconduct in Research". Psychiatric Annals 26(10):669-675, 1996.

394. Klein, DF: Panic disorder and agoraphobia: Hypothesis hothouse. J Clin Psychiatry 57(suppl 6):21-27, 1996.

395. Papp, LA, Martinez, JM, Klein, DF, Coplan, JD, Norman, RG, Cole, R, de Jesus, MJ, Ross, D, Goetz, R, Gorman, JM: Respiratory psychophysiology of panic disorder: Three respiratory challenges in 98 subjects. Am J Psychiatry 154(11):1557-1565, 1997.

396. Coplan, JD, Papp, LA, Pine, D, Martinez, J, Cooper, T, Rosenblum, LA, Klein, DF & Gorman, JM: Clinical improvement with fluoxetine therapy and noradrenergic function in patients with panic disorder. Arch Gen Psychiatry 54(7):643-648, 1997.

397. Donovan, SJ, Susser, ES, Nunes, EV, Stewart, JW, Quitkin, FM & Klein, DF: Divalproex treatment of disruptive adolescents: A report of 10 cases. J Clin Psychiatry 58(1):12-15, 1997.

398. Klein, DF, Smith, LB. A psychotherapeutic context for pharmacotherapy trials is promising, but manualization is not. Arch Gen Psychiatry 54(10):929-930, 1997.

399. Papp, LA, Schneier, FR, Fyer, AJ, Liebowitz, MR, Gorman, JM, Coplan, JD, Saoud, J, Campeas, R, Fallon, B, Jusino, C, Klein, DF: Clomipramine treatment of panic disorder: Pro's and con's. J Clin Psychiatry 58(10):423-425, 1997.

400. Gorman, JM, Browne, ST, Papp, LA, Martinez, J, Welkowitz, L, Coplan, JD, Goetz, RR, Kent, J, Klein, DF: Effect of antipanic treatment on response to carbon dioxide. Biol Psychiatry 42:982-991, 1997.

401. Klein, DF: Control groups in pharmacotherapy and psychotherapy evaluations. Prevention and Treatment, http://journals.apa.org/treatment/vol1/97_a1.html, posted 9/22/97.

402. Fallon, BA, Liebowitz, MR, Campeas, R, Schneier, FR, Marshall, R, Davies, S, Goetz, D, Klein, DF: Intravenous clomipramine for obsessive compulsive disorder refractory to oral clomipramine: A placebo controlled study. Arch Gen Psychiatry 55(10):918-924, 1998.

403. Heimberg, RG, Liebowitz, MR, Schneier, FR, Hope, DA, Holt, CS, Welkowitz, LA, Juster, HR, Campeas, R, Bruch, MA, Cloitre, M, Fallon, B, Klein, DF: Cognitive-behavioral group therapy vs phenelzine therapy for social phobia: 12-week outcome. Arch Gen Psychiatry 55(12):1133-1141, 1998.

404. Stewart, JW, Garfinkel, R, Nunes, EV, Donovan, S, Klein, DF: Atypical features and treatment response in the National Institute of Mental Health Treatment of Depression Collaborative Research Program. J Clin Psychopharm 18(6):429-434, 1998.

405. Klein, RG, Pine, DS, Klein, DF: Mania is mistaken for ADHD in prepubertal children. A debate (against). J Am Acad Child Adolesc Psychiatry 37(10):1093-1096; 1098-1099, 1998.

406. Quitkin, FM, McGrath, PJ, Stewart, JW, Ocepek-Welikson, K, Taylor, BP, Nunes, E, Deliyannides, D, Agosti, V, Donovan, SJ, Ross, D, Petkova, E, & Klein, DF: Placebo run-in period in studies of depressive disorders; Clinical, heuristic and research implications. Br J Psychiatry 242-248, 1998.
407. Salman, E, Liebowitz, MR, Guarnaccia, PJ, Jusino, CM, Garfinkel, R, Street, L, Cardenas, DL, Silvestre, J, Fyer, AJ, Carrasco, JL, Davies, SO, & Klein, DF. Subtypes of ataques de nervios: The influence of coexisting psychiatric diagnosis. Culture, Medicine and Psychiatry 22(2):231-244, 1998.

408. Simpson, HB, Schneier, FR, Campeas, RB, Marshall, RD, Fallon, BA, Davies, S, Klein, DF, Liebowitz, MR: Imipramine in the treatment of social phobia. J Clin Psychopharmacology 18(2):132-135, 1998.

409. Klein, DF: The significance of panic in general medicine (Editorial). J Psychosomatic Research 44(1):17-19, 1998.

410. Pine, DS, Coplan, JD, Papp, LA, Klein, RG, Martinez, JM, Kovalenko, P, Tancer, N, Moreau, D, Dummit, ES, Shaffer, D, Klein, DF, Gorman, JM: Ventilatory physiology of children and adolescents with anxiety disorders. Arch Gen Psychiatry 55(2):123-129, 1998.

411. Coplan, JD, Goetz, R, Klein, DF, Papp, LA, Fyer, AJ, Liebowitz, MR, Davies, SO, Gorman, JM: Plasma cortisol concentrations preceding lactate-induced panic; Psychological, biochemical, and physiological correlates. Arch Gen Psychiatry 55(2):130-136, 1998.

412. Klein, DF: Commentary: The treatment of panic. Psychopharm Bull 34(2):197, 1998.

413. Martinez, JM, Coplan, JD, Browne, ST, Goetz, R, Welkowitz, LA, Papp, LA, Klein, DF, Gorman, JM: Hemodynamic response to respiratory challenges in panic disorder. J Psychosom Res 44(1):153-161, 1998.

414. Klein, DF: Listening to meta-analysis but hearing bias. Prevention and Treatment
http://journals.apa.org/prevention/volume1/pre0010008r.html, posted 6/26/98.

415. Klein, DF: Reply to Kirsch's rejoinder regarding antidepressant meta-analysis. Prevention and Treatment. http://journals.apa.org/prevention/volume1/pre0010008r.html, posted 11/20/98.

416. Knowles, JA, Fyer, AJ, Vieland, VJ, Weissman, MM, Hodge, SE, Heiman, GA, Haghighi, F, de Jesus, GM, Rassnick, H, Preud'homme-Rivelli, X, Austin, T, Cunjak, J, Mick, S, Fine, LD, Woodley, KA, Das, K, Maier, W, Adams, PB, Freimer, NB, Klein, DF, Gilliam, TC: Results of a genome-wide genetic screen for panic disorder. American Journal of Medical Genetics (Neuropsychiatric Genetics) 81:130-147, 1998.

417. Klein, DF: Panic and phobic anxiety: Phenotypes, endophenotypes, and genotypes. Am J Psychiatry 155(9):1147-1149, 1998.

418. Lipsitz, JD, Mannuzza, S, Klein, DF, Ross, DC, Fyer, AJ. Specific phobia 10-16 years after treatment. Depression & Anxiety 10:105-111, 1999.

419. Klein, DF: Harmful dysfunction, disorder, disease, illness, and evolution. J Abnorm Psychol 108(3):421-429, 1999.

420. Klein, DF: Dealing with the effects of therapy allegiances. Clin Psychol: Sci & Practice 6:124-126, 1999.

421. Klein, DF: Evidence for the Validity of the Concept of Panic Disorder. European Neuropsychopharmacology 8(supl 2) S57-60, 1998.

422. Hamilton, SP, Heiman, GA, Haghigi, FG, Mick, S, Klein, DF, Hodge, SE, Weissman, MM, Fyer, AJ, Knowles, JA. Lack of genetic linkage or association between a functional serotonin transporter polymorphism and panic disorder. Psychiatric Genetics 9:1-6, 1999.

423. Klein, DF, Smith, LB: Organizational requirements for effective clinical effectiveness studies. Prevention and Treatment http://journals.apa.org/prevention/volume2/pre0020002a.html, posted March 21, 1999.

424. Klein, DF: (Commentary) The report by the Institute of Medicine and Postmarketing Surveillance. Arch Gen Psychiatry 56(4):353-354, 1999.

425. Coplan, JD, Tamir, H, Calaprice, D, de Jesus, MJ, de la Nuez, M, Pine, D, Papp, LA, Klein, DF & Gorman, JM: Plasma anti-serotonin and serotonin anti-idiotypic antibodies are elevated in panic disorder. Neuropsychopharmacology 20(4):386-391, 1999.

426. Sinha, SS, Coplan, JD, Pine, DS, Martinez, JA, Klein, DF & Gorman, JM: Panic induced by carbon dioxide inhalation and lack of hypothalamic-pituitary-adrenal axis activation. Psychiatry Res 86:93-98, 1999.

427. Breslau, N & Klein, DF: Smoking and panic attacks: An epidemiologic investigation. Arch Gen Psychiatry 56(12):1141-1147, 1999.

428. Sinha, SS, Goetz, R, Klein, DF: Non-fearful panic induction in normals with naloxone pretreatment of lactate infusion. Submitted Psychiatry Research.

429. Liebowitz, MR, Heimberg, RG, Schneier, FR, Hope, DA, Davies, S, Holt, CS, Goetz, D, Juster, HR, Lin, S-H, Bruch, MA, Marshall, RD, Klein, DF: Cognitive-behavioral group therapy versus phenelzine in social phobia: Long term outcome. Depression and Anxiety 10:89-98, 1999.

430. Hamilton, SP, Haghighi, F, Heiman, GA, Klein, DF, Hodge, SE, Fyer, AJ, Weissman, M